Fosgonimeton features a peptide-derived molecular architecture used to study receptor-associated interactions and structural adaptability. Its residues generate a balanced hydrophobic-polar environment that supports folding analysis. Researchers examine its behavior in solution to map binding equilibria. Applications include ligand-design research, peptide engineering, and biophysical characterization.
CAT No: R2347
CAS No:2093305-05-4
Synonyms/Alias:Fosgonimeton;2093305-05-4;Fosgonimeton [INN];Fosgonimeton [USAN];H91OA9858J;UNII-H91OA9858J;Fosgonimeton [USAN:INN];ATH-1017 FREE ACID;WHO 11782;L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-,;L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;Fosgonimeton (USAN/INN);NDX-1017 FREE ACID;CHEMBL5095419;AKOS040757261;DA-63589;HY-132814;CS-0204081;D12392;G18373;[4-[(2S)-3-[[(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl]amino]-2-(hexanoylamino)-3-oxopropyl]phenyl] dihydrogen phosphate;dihydrogen 4-[(2S)-3-({(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl}amino)-2-hexanamido-3-oxopropyl]phenyl phosphate;L-ISOLEUCINAMIDE, O-(PHOSPHONO-.KAPPA.O)-N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-,;
Fosgonimeton is a small-molecule prodrug that has garnered significant attention in biochemical research due to its unique mechanism of action and neuroactive properties. As a synthetic compound designed to modulate neurotrophic pathways, it serves as a precursor to the active metabolite ATH-1001, which is known to influence synaptic function and neuronal signaling. Its structure and pharmacological profile make it a valuable tool for researchers investigating synaptic plasticity, neuroprotection, and the molecular underpinnings of cognitive processes. Fosgonimeton's relevance extends to studies focused on neurodegenerative disorders, neuronal repair mechanisms, and the broader field of central nervous system (CNS) biology, reflecting its versatility as a research-use-only compound.
Neurobiology research: In the context of neurobiology, fosgonimeton is frequently employed to explore mechanisms regulating synaptic plasticity and neuronal communication. Its conversion to the active metabolite enables modulation of the hepatocyte growth factor (HGF)/MET signaling pathway, which plays a pivotal role in neuronal survival, differentiation, and synaptic maintenance. Researchers utilize fosgonimeton to dissect the contribution of neurotrophic signaling to cognitive function, neuronal network integrity, and adaptive responses to injury or disease-related stressors in vitro and in vivo experimental models.
Mechanistic studies of neurotrophic pathways: Fosgonimeton provides a practical approach for elucidating the molecular interactions and downstream effects of HGF/MET activation within the CNS. By serving as a selective modulator, it allows scientists to investigate the cascade of intracellular events triggered by neurotrophic factors, including alterations in gene expression, protein phosphorylation, and synaptic remodeling. Such studies are critical for mapping the cellular events that underpin learning, memory, and neuroprotection, offering insights into the fundamental biology of neural tissues.
Neuroprotection assays: The compound is widely used in neuroprotection assays to assess its impact on neuronal viability under conditions of oxidative stress, excitotoxicity, or other cellular insults. By modulating neurotrophic signaling, fosgonimeton enables researchers to characterize protective mechanisms and identify molecular targets that may buffer neurons against degenerative processes. These applications are essential for advancing the understanding of cellular resilience and vulnerability in models of neurodegeneration and CNS injury.
Electrophysiological investigations: Fosgonimeton is also valuable in electrophysiological studies aimed at characterizing changes in synaptic transmission and network activity. Its ability to influence synaptic function through neurotrophic signaling makes it suitable for experiments measuring long-term potentiation, synaptic plasticity, and neuronal excitability. Such research contributes to a deeper understanding of how neuroactive compounds can modulate electrical properties of neural circuits, supporting the development of new experimental paradigms in neuroscience.
Drug discovery and target validation: In the realm of early-stage drug discovery, fosgonimeton serves as a reference compound for validating the HGF/MET pathway as a therapeutic target. Its well-characterized mechanism provides a benchmark for screening novel modulators and assessing their efficacy in modulating neurotrophic signaling. Researchers leverage its properties to design structure-activity relationship (SAR) studies, optimize lead compounds, and establish robust experimental systems for preclinical evaluation. This makes it a critical tool in the translational pipeline from basic neurobiology to the identification of potential pharmacological interventions for neurological disorders.
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