Fosgonimeton features a peptide-derived molecular architecture used to study receptor-associated interactions and structural adaptability. Its residues generate a balanced hydrophobic-polar environment that supports folding analysis. Researchers examine its behavior in solution to map binding equilibria. Applications include ligand-design research, peptide engineering, and biophysical characterization.
CAT No: R2347
CAS No:2093305-05-4
Synonyms/Alias:Fosgonimeton;2093305-05-4;Fosgonimeton [INN];Fosgonimeton [USAN];H91OA9858J;UNII-H91OA9858J;Fosgonimeton [USAN:INN];ATH-1017 FREE ACID;WHO 11782;L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-,;L-Isoleucinamide, O-(phosphono-kappaO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;Fosgonimeton (USAN/INN);NDX-1017 FREE ACID;CHEMBL5095419;AKOS040757261;DA-63589;HY-132814;CS-0204081;D12392;G18373;[4-[(2S)-3-[[(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl]amino]-2-(hexanoylamino)-3-oxopropyl]phenyl] dihydrogen phosphate;dihydrogen 4-[(2S)-3-({(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl}amino)-2-hexanamido-3-oxopropyl]phenyl phosphate;L-ISOLEUCINAMIDE, O-(PHOSPHONO-.KAPPA.O)-N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-,;
Fosgonimeton, also known as ATH-1017, is a novel prodrug designed to enhance synaptic function and neuronal health by targeting the hepatocyte growth factor (HGF)/MET signaling pathway. As a small-molecule compound, it is engineered for efficient brain penetration and rapid conversion to its active metabolite, thereby facilitating neurotrophic and neuroprotective effects. Its unique mechanism of action distinguishes it from traditional neuroactive agents, offering a promising avenue for research focused on modulating synaptic plasticity, promoting neuronal survival, and supporting cognitive resilience. The compound's chemical stability and favorable pharmacokinetic properties make it a versatile tool for in vitro and in vivo studies, enabling detailed exploration of neurobiological processes underlying learning, memory, and neurodegeneration.
Neurodegenerative Disease Research: Fosgonimeton serves as a valuable research tool in the study of neurodegenerative diseases, particularly those characterized by synaptic dysfunction and neuronal loss. By activating the HGF/MET pathway, it promotes neurogenesis and synaptic repair, allowing scientists to investigate the molecular mechanisms that underlie neuronal resilience. Researchers can utilize the compound to model disease progression, assess the efficacy of neurotrophic interventions, and elucidate signaling pathways involved in neuroprotection. Its ability to modulate key biomarkers of neuronal health provides insight into therapeutic strategies aimed at slowing or reversing neurodegeneration.
Cognitive Function Studies: In the field of cognitive neuroscience, ATH-1017 is employed to explore the regulation of memory formation, learning, and synaptic plasticity. Its neurotrophic activity supports the maintenance and strengthening of synaptic connections, which are critical for cognitive processes. Experimental models benefit from the compound's capacity to enhance long-term potentiation and facilitate the recovery of cognitive function following injury or stress. By using Fosgonimeton in preclinical models, researchers can dissect the contributions of the HGF/MET pathway to cognitive resilience and identify potential targets for cognitive enhancement.
Synaptic Plasticity Investigation: Fosgonimeton enables detailed examination of synaptic plasticity mechanisms at the molecular and cellular levels. Its action on the HGF/MET axis allows for the study of dendritic spine formation, synaptic remodeling, and neurotransmitter release. Scientists can employ the compound in neuronal cultures or animal models to observe changes in synaptic architecture, monitor electrophysiological responses, and quantify alterations in synaptic protein expression. These investigations shed light on the dynamic processes that support learning and adaptation in the nervous system.
Neurotrophic Signaling Pathway Analysis: As a modulator of neurotrophic signaling, ATH-1017 is instrumental in dissecting the complex interactions within the HGF/MET pathway. Researchers can leverage its selective activation properties to map downstream signaling cascades, including those involving PI3K/Akt and MAPK/ERK. The compound enables precise manipulation of neurotrophic factor levels, facilitating studies on cell survival, differentiation, and axonal outgrowth. Its application in pathway analysis contributes to a deeper understanding of the molecular basis for neuronal maintenance and regeneration.
Drug Discovery and Screening: Fosgonimeton is increasingly utilized in drug discovery programs focused on identifying novel neuroprotective agents. Its well-characterized mechanism of action and robust effects on neuronal health make it an ideal reference compound for high-throughput screening assays. By incorporating ATH-1017 into compound libraries, researchers can evaluate the neurotrophic potential of new molecules, assess synergistic interactions, and prioritize candidates for further development. The compound's versatility supports the advancement of innovative therapeutics targeting neurodegenerative and cognitive disorders.
In summary, Fosgonimeton offers multifaceted applications across neurodegenerative disease research, cognitive function studies, synaptic plasticity investigation, neurotrophic signaling pathway analysis, and drug discovery efforts. Its unique pharmacological profile and capacity to modulate key neurobiological processes position it as a valuable asset for advancing the understanding of neuronal health and resilience. Through its integration into diverse research paradigms, the compound continues to drive progress in elucidating the mechanisms underlying brain function and dysfunction.
1. Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
3. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More