G-Protein antagonist peptide

Substance P-related peptide which inhibits the binding of G protein to its receptor. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
G-Protein antagonist peptide(CAS 143675-79-0)

CAT No: R0855

CAS No:143675-79-0

Synonyms/Alias:G Protein Antagonist;143675-79-0;PYR-GLN-D-TRP-PHE-D-TRP-D-TRP-MET-NH2;G-Protein antagonist peptide;(2S)-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanediamide;pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2;DTXSID70745572;MFCD03444578;AKOS024456865;DA-53458;FG110327;PD079219;G Protein Antagonist Pyr-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2;5-Oxo-L-prolyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-D-tryptophyl-L-methioninamide;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C57H64N12O9S
M.W/Mr.
1093.3
Sequence
One Letter Code:XQWFWWM
Three Letter Code:H-Pyr-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2
Appearance
White solid powder
Purity
>98 %
Activity
Inhibitor
Long-term Storage Conditions
Soluble in DMSO
Solubility
-20 °C
InChI
InChI=1S/C57H64N12O9S/c1-79-24-23-42(51(59)72)64-55(76)46(26-33-29-60-39-16-8-5-13-36(33)39)69-57(78)48(28-35-31-62-41-18-10-7-15-38(35)41)68-54(75)45(25-32-11-3-2-4-12-32)66-56(77)47(27-34-30-61-40-17-9-6-14-37(34)40)67-53(74)44(19-21-49(58)70)65-52(73)43-20-22-50(71)63-43/h2-18,29-31,42-48,60-62H,19-28H2,1H3,(H2,58,70)(H2,59,72)(H,63,71)(H,64,76)(H,65,73)(H,66,77)(H,67,74)(H,68,75)(H,69,78)/t42-,43-,44-,45-,46+,47+,48+/m0/s1
InChI Key
WSYRBHQWMXTCHQ-SFIKJRKMSA-N
Isomeric SMILES
CSCC[C@@H](C(=O)N)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@@H](CC6=CNC7=CC=CC=C76)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]8CCC(=O)N8
BoilingPoint
N/A
Melting Point
N/A

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