Galanin is a 29-aa neuropeptide with a complex role in pain processing. Galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. Three galanin receptors, GalR1, GalR2, and GalR3, have been identified and cloned. AR-M1896 is a specific galanin R2 (GalR2) agonist.
CAT No: R1888
CAS No:367518-31-8
Synonyms/Alias:WTLNSAGYLL-CONH2;367518-31-8;Galanin (2-11) porcine, rat;AR-M1896;CHEMBL578710;Galanin (2-11) amide trifluoroacetate salt;Galanin-2-11-NH..2..;Galanin(2-11)porcine,rat;Alternative Name: Gal(2-11)amide;HY-P1129;BDBM50307252;AKOS024457247;DA-63669;FG110166;CS-0028038;Galanin (2-11) porcine, rat, >=97% (HPLC), lyophilized powder;H-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2; H-WTLNSAGYLL-NH2;
Galanin (2-11) (AR-M 1896) is a synthetic peptide fragment derived from the endogenous neuropeptide galanin, comprising amino acids 2 through 11 of the native sequence. As a truncated analogue, it exhibits selective receptor interaction properties distinct from the full-length peptide, making it a valuable tool for dissecting the functional roles of galanin receptors in neurobiology and endocrinology. Its structural characteristics confer unique binding affinities and signaling profiles, enabling researchers to investigate the mechanisms underlying galanin-mediated processes such as neurotransmission, hormone secretion, and neuronal modulation. The compound's specificity and stability support its extensive use in experimental systems aimed at elucidating peptide-receptor dynamics and downstream biological effects.
Receptor Subtype Characterization: Galanin (2-11) is widely employed in studies focused on characterizing the pharmacological profiles of galanin receptor subtypes, particularly GALR2 and GALR3. Its selective activity allows researchers to distinguish between receptor-mediated pathways, facilitating the mapping of receptor distribution and function in various tissues. By utilizing this peptide fragment, investigators can isolate specific galanin receptor responses, thereby advancing the understanding of receptor-ligand interactions in both central and peripheral nervous system contexts.
Signal Transduction Analysis: In cellular and molecular neuroscience, the peptide serves as a critical probe for dissecting intracellular signaling cascades initiated by galanin receptor activation. Its ability to preferentially activate certain receptor subtypes enables detailed examination of downstream effectors such as G-protein coupled signaling, second messenger systems, and gene expression modulation. This application is instrumental in unraveling the molecular mechanisms by which galanin influences neuronal excitability, synaptic plasticity, and neuroendocrine regulation.
Neuropeptide Function Studies: The compound is routinely utilized to investigate the physiological and biochemical functions of galanin-derived peptides in neuronal and endocrine systems. Researchers employ it to probe the roles of galanin fragments in modulating neurotransmitter release, hormone secretion, and neurotrophic processes. Its use in in vitro and ex vivo models provides insight into the differential effects of galanin fragments compared to the full-length peptide, contributing to a more nuanced understanding of peptide function in health and disease models.
Peptide Structure-Activity Relationship Research: Galanin (2-11) supports structure-activity relationship (SAR) studies aimed at delineating the key amino acid residues responsible for receptor binding and biological activity. By comparing the functional outcomes of this fragment with those of other galanin analogues, scientists can identify critical structural motifs that govern receptor selectivity and efficacy. Such SAR investigations inform the rational design of novel peptide ligands with tailored pharmacological properties for research applications.
Peptide Synthesis and Analytical Validation: The peptide also serves as a reference standard in peptide synthesis protocols and analytical method development. Its defined sequence and known bioactivity make it a suitable benchmark for validating synthetic methodologies, optimizing purification strategies, and calibrating analytical instruments. Researchers involved in peptide chemistry and quality control utilize it to ensure the fidelity and consistency of peptide production processes, thereby supporting reproducible experimental outcomes across diverse research settings.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More