IGF-1 LR3 is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).
CAT No: 10-101-260
CAS No:946870-92-4
Synonyms/Alias:946870-92-4;CAMELLIA SINENSIS LEAF OIL;2-[4-[2-[3-[bis[(9Z,12Z)-2-hydroxyoctadeca-9,12-dienyl]amino]propyldisulfanyl]ethyl]piperazin-1-yl]ethyl 5-[bis(2-hydroxytetradecyl)amino]pentanoate;
IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic analog of the naturally occurring IGF-1 peptide, distinguished by an extended amino acid sequence that enhances its biological stability and activity. This engineered protein features a substitution of arginine for glutamic acid at the third position and an additional 13 amino acids at the N-terminus, resulting in increased resistance to degradation by IGF-binding proteins. As a result, IGF-1 LR3 exhibits a significantly prolonged half-life and greater bioavailability compared to native IGF-1. Its unique structural attributes make it an invaluable reagent in a variety of scientific and research settings, especially where sustained IGF-1 signaling is required. Researchers value this peptide for its ability to robustly activate IGF-1 receptors, thereby stimulating a wide array of cellular processes linked to growth, metabolism, and differentiation.
Cellular Proliferation Studies: IGF-1 LR3 is extensively utilized in cellular biology research to investigate mechanisms of cell growth and proliferation. Its potent agonistic action on the IGF-1 receptor facilitates studies focused on the regulation of cell cycle progression, survival, and differentiation. By providing a consistent and prolonged stimulus, it enables researchers to more accurately assess the downstream effects of IGF-1 signaling pathways in various cell types, including fibroblasts, myoblasts, and epithelial cells. This makes it an essential tool for dissecting the molecular underpinnings of tissue development and regeneration.
Protein Synthesis Research: In the context of protein biosynthesis, IGF-1 analogs are frequently employed to evaluate their impact on anabolic pathways within cultured cells. IGF-1 LR3, due to its enhanced activity, serves as a powerful agent to stimulate mTOR and related signaling cascades, thereby promoting translation initiation and protein assembly. Such applications are crucial for understanding how extracellular signals modulate cellular growth and metabolism, offering insights into both physiological and pathological states such as hypertrophy or muscle wasting.
Stem Cell Differentiation: IGF-1 LR3 finds significant application in stem cell research, where it is used to direct the fate of pluripotent and multipotent cell populations. By modulating the extracellular environment with this peptide, scientists can influence lineage commitment and maturation of stem cells into specific cell types, such as osteoblasts, chondrocytes, or myocytes. This capability is particularly valuable for regenerative medicine studies and for developing in vitro tissue models that recapitulate key aspects of human development and disease.
Tissue Engineering: The extended activity of IGF-1 LR3 makes it an attractive component in tissue engineering protocols, where sustained growth factor signaling is necessary for the formation and maintenance of engineered tissues. Its ability to promote cellular proliferation, matrix production, and survival supports the development of functional tissue constructs in vitro. Researchers incorporate it into scaffold materials or culture media to optimize the growth and integration of cells within three-dimensional environments, advancing the field of biofabrication and organoid generation.
Metabolic Regulation Studies: IGF-1 LR3 is also instrumental in metabolic research, particularly for elucidating the role of IGF-1 signaling in glucose and lipid metabolism. Through its effects on insulin sensitivity and nutrient uptake, the peptide provides a model system for studying metabolic homeostasis in various cell types. This application aids in the exploration of fundamental metabolic processes and the identification of novel regulatory mechanisms that could inform future research in metabolic disorders.
Signal Transduction Analysis: In addition to its primary roles in growth and metabolism, IGF-1 LR3 is leveraged in studies aimed at dissecting complex signal transduction networks. Its robust and sustained activation of the IGF-1 receptor enables researchers to map downstream effectors and cross-talk with other signaling pathways, including those mediated by insulin, growth hormone, and cytokines. These investigations contribute to a more comprehensive understanding of cellular communication and the integration of extracellular cues, supporting the development of new hypotheses in cell biology and molecular medicine.
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