Irucalantide is a peptide analog with aromatic and charged residues that create distinct conformational states. Researchers use it to examine β-turn formation, backbone flexibility, and peptide-protein recognition. The sequence supports folding analyses under varied solvent conditions. Its architecture suits comprehensive biophysical evaluation.
CAT No: R2501
CAS No:1631160-47-8
Synonyms/Alias:Irucalantide;1631160-47-8;irucalantide [INN];OV42G2O3SQ;HY-P5536;DA-54386;CS-0886413;L-Cysteinamide, N-acetyl-S-[[3,5-bis(mercaptomethyl)phenyl]methyl]-L-cysteinyl-L-seryl-L-phenylalanyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-N6-(aminoiminomethyl)-L-lysyl-L-cysteinyl-L-alanyl-psi(CH2-NH)-L-histidyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-, cyclic (1-->7),(1-->13)-bis(thioether);
Irucalantide is a synthetic peptide compound structurally designed to mimic and modulate specific biological signaling pathways. As a member of the peptide class, it is characterized by a defined amino acid sequence that enables targeted interactions with cellular receptors, making it a valuable tool for probing peptide-receptor dynamics and underlying mechanisms in physiological systems. Its stability, bioactivity, and selectivity have attracted significant interest in the fields of peptide research and molecular pharmacology, where it serves as a model compound for elucidating peptide-mediated processes. The unique properties of irucalantide make it especially relevant for investigations requiring precise modulation of peptide signaling, as well as for the development of novel peptide-based assays and analytical methodologies.
Receptor binding studies: Irucalantide is widely utilized in receptor binding assays to characterize the affinity and specificity of peptide-receptor interactions. Researchers employ it to dissect the molecular determinants of binding, allowing for detailed mapping of ligand recognition sites and the elucidation of structure-activity relationships. Its well-defined sequence and bioactivity profile make it an ideal standard in competitive binding experiments, supporting the development of new ligands and the validation of novel receptor targets within complex biological systems.
Signal transduction research: The compound plays a pivotal role in exploring intracellular signaling cascades initiated by peptide ligands. By serving as a selective agonist or modulator in cell-based assays, it enables researchers to dissect downstream effects such as second messenger generation, phosphorylation events, and gene expression changes. These studies provide critical insights into the functional consequences of peptide-receptor engagement and facilitate the identification of key regulatory nodes within signaling networks.
Peptide functional analysis: Irucalantide is an essential reagent for functional characterization of peptide analogs and derivatives. In comparative studies, it is used as a reference compound to assess the potency, efficacy, and selectivity of newly synthesized peptides. This application is crucial for optimizing peptide design and for understanding how subtle modifications in sequence or structure impact biological activity, informing both basic research and the rational design of future peptide tools.
Analytical method development: The peptide's defined chemical structure and stability render it suitable for the development and validation of analytical techniques such as liquid chromatography, mass spectrometry, and capillary electrophoresis. It is frequently employed as a calibration standard or quality control reference in peptide quantification workflows, ensuring accuracy and reproducibility in the measurement of peptide concentrations in complex matrices. These analytical applications are essential for advancing peptide-based research and for supporting high-throughput screening initiatives.
Peptide synthesis optimization: Irucalantide serves as a model substrate in the optimization of solid-phase peptide synthesis protocols. Its sequence complexity and known folding properties allow synthetic chemists to evaluate coupling efficiencies, resin compatibility, and purification strategies. By monitoring the yield and integrity of the synthesized product, researchers can refine synthetic methodologies, troubleshoot challenging sequences, and enhance overall process efficiency, thereby facilitating the production of high-quality peptides for diverse research applications.
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