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K-(D-1-Nal)-FwLL-NH2

K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively), which blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R0816

CAS No:1394288-22-2

Synonyms/Alias:K-(D-1-Nal)-FwLL-NH2;1394288-22-2;CHEMBL2170781;(2S)-2,6-diamino-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]hexanamide;L-Lysyl-3-(1-naphthalenyl)-D-alanyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide;1394288-32-4;GLXC-25344;BDBM50396915;AKOS027470298;DA-64682;PD079927;Lys-(D-1-Nal)-Phe-D-Trp-Leu-Leu-NH2;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C51H67N9O6
M.W/Mr.
902.1
Sequence
One Letter Code:KXFWLL
Three Letter Code:H-Lys-D-1Nal-Phe-D-Trp-Leu-Leu-NH2
Labeling Target
Ghrelin receptor
Application
K-(D-1-Nal)-FwLL-NH2 is an inverse agonist of the ghrelin receptor.
Purity
>98 %
Activity
Agonist
InChI
InChI=1S/C51H67N9O6/c1-31(2)25-41(46(54)61)56-48(63)42(26-32(3)4)58-51(66)45(29-36-30-55-40-23-11-10-21-38(36)40)60-49(64)43(27-33-15-6-5-7-16-33)59-50(65)44(57-47(62)39(53)22-12-13-24-52)28-35-19-14-18-34-17-8-9-20-37(34)35/h5-11,14-21,23,30-32,39,41-45,55H,12-13,22,24-29,52-53H2,1-4H3,(H2,54,61)(H,56,63)(H,57,62)(H,58,66)(H,59,65)(H,60,64)/t39-,41-,42-,43-,44+,45+/m0/s1
InChI Key
NCMQVOQOKBIHPA-MHRDGXECSA-N
Isomeric SMILES
CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H](CC4=CC=CC5=CC=CC=C54)NC(=O)[C@H](CCCCN)N

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