Kisspeptin-10 is a potent endogenous agonist for GPR54, used as a vasoconstrictor and an angiogenesis inhibitor.
CAT No: R1469
CAS No:374675-21-5
Synonyms/Alias:Kisspeptin-10;374675-21-5;Metastin (45-54);Kisspeptin-10 (human);KP-10;Human kisspeptin 10F;Metastin 45-54;UNII-FS1N52VS3S;FS1N52VS3S;CHEMBL376756;NSC 741805;Kisspeptin-10, human;KP10;Kisspeptin 10;Kisspeptin-10?;KISS1;Human metastin 45-54;Kisspeptin-10 TFA salt;GTPL1281;GTPL1283;Kisspeptin-13 (4-13) (human) trifluoroacetate salt;SCHEMBL15930211;BDBM26349;[125I]kisspeptin-10 (human);RITKWYDZSSQNJI-INXYWQKQSA-N;EX-A5793;BDBM50045513;AKOS024457174;[125I]-KP10;[125I]KP-10;DA-74772;FK109536;Metastin (45-54) amide, human, >=95%;G13213;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-AMINO-3-(4-HYDROXYPHENYL)PROPANAMIDO]-3-CARBAMOYLPROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]-N-[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-4-CARBAMIMIDAMIDO-1-{[(1S)-1-CARBAMOYL-2-PHENYLETHYL]CARBAMOYL}BUTYL]CARBAMOYL}-3-METHYLBUTYL]CARBAMOYL}METHYL)CARBAMOYL]-2-PHENYLETHYL]CARBAMOYL}-2-HYDROXYETHYL]SUCCINAMIDE;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]butanediamido]-3-(1H-indol-3-yl)propanamido]-N-[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}methyl)carbamoyl]-2-phenylethyl]carbamoyl}-2-hydroxyethyl]butanediamide;Human kisspeptin 10F;L-Tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-phenylalan inamide;
Kisspeptin-10 is a synthetic decapeptide derived from the endogenous kisspeptin family, a group of neuropeptides known for their pivotal role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. As a biologically active fragment of kisspeptin, this peptide is recognized for its high affinity to the G protein-coupled receptor GPR54 (also known as KISS1R), making it a valuable tool for probing reproductive neuroendocrinology and signaling pathways. Its defined sequence and robust receptor specificity have established it as a standard reagent in studies of peptide-receptor interactions, neuroendocrine regulation, and peptide signaling dynamics. Kisspeptin-10's utility extends across diverse fields, from basic research in neurobiology to advanced biochemical assays investigating peptide-mediated cellular responses.
Neuroendocrine research: Kisspeptin-10 is widely employed in neuroendocrine studies to elucidate the molecular and cellular mechanisms underlying the regulation of gonadotropin-releasing hormone (GnRH) secretion. By acting as a potent agonist at KISS1R, it enables researchers to dissect the signaling cascades that control reproductive hormone release, facilitating investigations into the neural control of puberty onset, fertility, and reproductive axis homeostasis. Its consistent activity and receptor selectivity provide a reliable basis for modeling neuropeptide-driven endocrine events both in vitro and in ex vivo tissue systems.
Receptor pharmacology: In the context of receptor characterization and ligand-binding assays, this decapeptide serves as a reference agonist for GPR54/KISS1R studies. Researchers utilize it to map ligand-receptor interactions, assess receptor activation kinetics, and evaluate downstream intracellular signaling pathways such as calcium mobilization or MAPK phosphorylation. Such applications are crucial for understanding the pharmacodynamics of kisspeptin analogs and for screening novel modulators or antagonists targeting the kisspeptin signaling axis.
Peptide signaling pathway analysis: The compound is instrumental in dissecting the broader landscape of peptide-mediated signal transduction. By providing a defined stimulus, it enables the analysis of intracellular events following KISS1R activation, including gene expression changes, second messenger cascades, and feedback regulation mechanisms. These studies are fundamental for unraveling the complexity of neuropeptide signaling networks and for identifying cross-talk with other hormonal or neurotransmitter systems.
Peptide synthesis and structure-activity relationship (SAR) studies: Kisspeptin-10 is frequently used as a template or benchmark in peptide synthesis projects focused on optimizing bioactivity or stability. Its well-characterized sequence allows for systematic modifications, facilitating SAR investigations that probe the impact of amino acid substitutions or chemical modifications on receptor binding and functional activity. Such research supports the rational design of novel peptide analogs with tailored properties for experimental or industrial applications.
Analytical assay development: The defined molecular characteristics and receptor specificity of this peptide make it an ideal standard for developing and validating analytical methods, including ELISA, mass spectrometry, and high-performance liquid chromatography (HPLC). Its use as a calibration or positive control reagent enhances assay reliability in quantifying endogenous kisspeptin levels, monitoring peptide degradation, or benchmarking assay sensitivity in complex biological matrices. This capability is especially valuable in translational research settings where precise quantification of neuropeptides is required.
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