Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons .
CAT No: R1472
Kv3, Channel Containing Protein 567-585 is a synthetic peptide fragment derived from the intracellular region of the Kv3 voltage-gated potassium channel family. As a peptide corresponding to amino acids 567 to 585 of the channel protein, it serves as a valuable molecular tool in studies of potassium channel structure, function, and regulatory mechanisms. The Kv3 channel family is critical for shaping action potentials and enabling high-frequency firing in specific neuronal populations, making this peptide fragment particularly relevant for neurophysiological and biochemical research. Its defined sequence and origin allow for precise interrogation of protein-protein interactions, post-translational modifications, and epitope mapping within the Kv3 channel context.
Electrophysiological research: Synthetic peptides representing specific domains of ion channels are widely used to dissect the molecular determinants of channel gating and conductance. The 567-585 fragment of the Kv3 channel protein provides a means to investigate how this intracellular segment contributes to channel function, modulation by auxiliary proteins, or interaction with cytoplasmic signaling molecules. Incorporating this peptide into in vitro assays enables researchers to probe functional motifs involved in channel activation, inactivation, or pharmacological sensitivity, thus advancing the understanding of rapid repolarization mechanisms in excitable cells.
Antibody generation and validation: Peptide fragments derived from unique channel regions are frequently employed as immunogens for producing sequence-specific antibodies. The Kv3, Channel Containing Protein 567-585 peptide can be conjugated to carrier proteins and used to immunize animals, facilitating the development of polyclonal or monoclonal antibodies targeting the intracellular C-terminal domain of Kv3 channels. Such antibodies are essential for applications in immunohistochemistry, western blotting, and immunoprecipitation, enabling the selective detection and quantification of Kv3 channel expression in complex biological samples.
Protein-protein interaction studies: Many intracellular channel segments serve as binding sites for regulatory proteins, scaffolding molecules, or signaling partners. The 567-585 peptide fragment can be applied in pull-down assays, surface plasmon resonance, or other biophysical techniques to identify and characterize specific interaction partners of the Kv3 channel C-terminus. By mapping these interactions, researchers gain insight into the molecular networks that modulate channel localization, assembly, and activity in neuronal and non-neuronal cells.
Phosphorylation and post-translational modification analysis: The defined sequence of the Kv3 channel peptide allows for in vitro studies of site-specific phosphorylation or other post-translational modifications. Kinases or modifying enzymes can be incubated with the peptide to assess modification patterns, substrate specificity, or the functional consequences of such modifications on channel behavior. Mass spectrometry and related analytical approaches facilitate the precise mapping of modification sites, informing the design of further mutagenesis or functional studies in cellular systems.
Epitope mapping and structural studies: Synthetic peptides are instrumental in delineating antibody binding sites and mapping functional epitopes within larger protein complexes. The Kv3, Channel Containing Protein 567-585 fragment serves as a reference sequence for epitope mapping experiments, enabling researchers to localize antibody recognition sites and assess conformational or linear epitope accessibility. This information is critical for the rational design of diagnostic reagents, structural models, and for improving the specificity of immunological assays targeting Kv3 channels.
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