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L-R4W2

L-R4W2 is an antagonist of stereoselective vanilloid TRPV1 (VR1) receptor (IC50 ~ 0.1 µM), and blocks Ca2+ currents in dorsal root ganglion neurons. It is used as analgesic agent.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
L-R4W2(CAS 206350-79-0)

CAT No: R0877

CAS No:206350-79-0

Synonyms/Alias:206350-79-0;GIA35079;AKOS024456678;PD079068;G78937;(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-Amino-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-car bamimidamido-N-[(1S)-1-{[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]pentanamide;

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cGMP Peptide
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  • Drug master files (DMF) filing
M.F/Formula
C46H71N21O6
M.W/Mr.
1014.2
Sequence
One Letter Code:RRRRWW
Three Letter Code:H-Arg-Arg-Arg-Arg-Trp-Trp-NH2
Labeling Target
Vanilloid TRPV1 (VR1) receptor
Appearance
White lyophilised solid
Purity
>98 %
Activity
Antagonist
Long-term Storage Conditions
Soluble in water
Solubility
-20°C
InChI
InChI=1S/C46H71N21O6/c47-29(11-5-17-57-43(49)50)38(69)63-32(14-6-18-58-44(51)52)39(70)64-33(15-7-19-59-45(53)54)40(71)65-34(16-8-20-60-46(55)56)41(72)67-36(22-26-24-62-31-13-4-2-10-28(26)31)42(73)66-35(37(48)68)21-25-23-61-30-12-3-1-9-27(25)30/h1-4,9-10,12-13,23-24,29,32-36,61-62H,5-8,11,14-22,47H2,(H2,48,68)(H,63,69)(H,64,70)(H,65,71)(H,66,73)(H,67,72)(H4,49,50,57)(H4,51,52,58)(H4,53,54,59)(H4,55,56,60)/t29-,32-,33-,34-,35-,36-/m0/s1
InChI Key
MGQHBRDQUJRCLN-UJARKJSPSA-N
Isomeric SMILES
C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)N
BoilingPoint
N/A
Melting Point
N/A

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