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LPYFD-NH2

LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ) and protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
LPYFD-NH2(CAS 700361-48-4)

CAT No: R0821

CAS No:700361-48-4

Synonyms/Alias:LPYFD-NH2;700361-48-4;LPYFD;(3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid;Leu-Pro-Tyr-Phe-Asp amide;Leu-Pro-Tyr-Phe-Asp-amide;HY-P1060;AKOS024457970;PD070349;CS-0026093;(S)-4-Amino-3-((S)-2-((S)-2-((S)-1-((S)-2-amino-4-methylpentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-phenylpropanamido)-4-oxobutanoic acid;

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C33H44N6O8
M.W/Mr.
652.7
Sequence
One Letter Code:LPYFD
Three Letter Code:H-Leu-Pro-Tyr-Phe-Asp-NH2
Labeling Target
Amyloid beta (Aβ)
Application
Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.
Solubility
-20 °C
InChI
InChI=1S/C33H44N6O8/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42)/t23-,24-,25-,26-,27-/m0/s1
InChI Key
IZXBZWOUOODINS-IRGGMKSGSA-N
Isomeric SMILES
CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC(=O)O)C(=O)N)N
BoilingPoint
N/A
Melting Point
N/A

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