Lucinactant contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid.
CAT No: 10-101-341
CAS No:1802925-00-3
Synonyms/Alias:L-Lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysine, acetate; Sinapultide acetate
Chemical Name:acetic acid;(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid
Lucinactant, also known as synthetic surfactant KL4, represents a significant advancement in the field of pulmonary research due to its unique peptide-containing surfactant formulation. Engineered to mimic the function of endogenous lung surfactant, Lucinactant consists of a synthetic peptide analog designed to replicate the activity of surfactant protein B, combined with a blend of phospholipids and fatty acids. This composition enables it to effectively reduce surface tension within the alveoli, facilitating improved gas exchange and lung compliance. Its robust physicochemical stability and resistance to inactivation by serum proteins make it an invaluable tool in laboratory investigations focused on respiratory biology and surfactant replacement strategies. By providing a reproducible and well-characterized alternative to animal-derived surfactants, Lucinactant supports a range of applications where consistency and ethical sourcing are critical.
Pulmonary Surfactant Research: Lucinactant is extensively utilized in studies aimed at elucidating the mechanisms of surfactant function and dysfunction in the lung. Its synthetic nature allows researchers to dissect the contribution of individual surfactant components to overall surface activity, providing a controlled system for examining the biophysical properties and interactions of surfactant proteins and lipids. Investigators leverage Lucinactant to model surfactant deficiency and restoration in vitro, enabling detailed analysis of alveolar stability and the prevention of atelectasis under various experimental conditions.
Respiratory Disease Modeling: The KL4 surfactant is a preferred agent in the development of in vitro and ex vivo models of respiratory diseases such as acute lung injury, acute respiratory distress syndrome, and surfactant deficiency disorders. Its reproducible composition and predictable biophysical behavior facilitate the study of pathophysiological changes in the alveolar environment, the assessment of surfactant metabolism, and the evaluation of therapeutic interventions. By using Lucinactant in these models, researchers can simulate clinical scenarios and investigate the efficacy of novel treatments or the impact of genetic and environmental factors on lung function.
Drug Delivery Studies: Synthetic surfactant formulations like Lucinactant are increasingly explored as vehicles for pulmonary drug delivery. Its ability to uniformly spread across the alveolar surface and interact with cell membranes makes it a promising carrier for hydrophobic drugs, peptides, or nucleic acids intended for targeted delivery to the respiratory tract. Researchers employ Lucinactant to assess the distribution, retention, and release profiles of therapeutic agents, as well as to optimize formulations for enhanced bioavailability and reduced toxicity in preclinical studies.
Toxicology and Safety Assessment: In toxicological research, Lucinactant serves as a standardized substrate for evaluating the pulmonary toxicity of inhaled substances, including environmental pollutants, aerosols, and nanoparticles. Its defined composition allows for reproducible assessment of surfactant inhibition, biophysical disruption, and cytotoxicity in lung cell cultures or isolated organ preparations. By providing a consistent background, Lucinactant enables researchers to distinguish compound-specific effects from variability associated with biological surfactants, thereby improving the reliability of safety assessments.
Biophysical and Structural Analysis: The synthetic surfactant is also instrumental in biophysical studies that probe the structure-function relationships of surfactant components. Researchers utilize Lucinactant in surface balance experiments, microscopy, and spectroscopy to investigate monolayer formation, interfacial rheology, and the molecular organization of surfactant films. These analyses yield insights into the mechanisms governing surfactant adsorption, spreading, and stability, informing the design of next-generation surfactant formulations with improved performance characteristics. Through its multifaceted applications, Lucinactant continues to advance fundamental and translational research in pulmonary science, surfactant biology, and respiratory therapeutics.
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