MEN 10376

Potent, highly selective NK2 neurokinin receptor antagonist.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
MEN 10376(CAS 135306-85-3)

CAT No: R1024

CAS No:135306-85-3

Synonyms/Alias:Men 10376;135306-85-3;MEN-10376;neurokinin A(4-10), Tyr(5)-Trp(6,8,9)-Lys(10)-;MEN-10,376;MFCD00144736;(3S)-3-amino-4-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid;CHEMBL507824;MEN10376;L-Lysinamide, L-alpha-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-;Neurokinin-2 receptor antagonist;(3S)-3-amino-4-(((2S)-1-(((2R)-1-(((2S)-1-(((2R)-1-(((2R)-1-(((2S)-1,6-diamino-1-oxohexan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid;5-Tyr-6,8,9-trp-10-lys-neurokinin A (4-10);GTPL2116;HY-P1276;BDBM50259674;Neurokinin A(4-10), tyrosyl(5)-tryptophyl(6,8,9)-lysine(10)-;AKOS030623006;NCGC00167321-01;DA-48909;CS-0029214;Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH(2);Q27084374;(Tyr5,D-Trp6.8.9,Lys-NH21?)-Neurokinin A (4-10);(Tyr5,D-Trp6?8?9,Lys-NH210)-Neurokinin A (4-10);L-Lysinamide,l-a-aspartyl-l-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-;(3S)-3-amino-3-{[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-{[(1R)-1-{[(1S)-5-amino-1-carbamoylpentyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}propanoic acid;(S)-3-amino-4-((S)-1-((R)-1-((S)-1-((R)-1-((R)-1-((S)-1,6-diamino-1-oxohexan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-4-oxobutanoic acid;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C57H68N12O10
M.W/Mr.
1081.2
Sequence
One Letter Code:DYWVWWK
Three Letter Code:H-Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2
Labeling Target
NK2 Receptors
Appearance
Off-white lyophilised solid
Purity
>99%
Activity
Antagonist
Long-term Storage Conditions
Soluble in Water
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
InChI
InChI=1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)/t40-,44-,45-,46+,47+,48+,50-/m0/s1
InChI Key
QQHOFZNACVKNHK-SXVLBCBNSA-N
Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CC=C(C=C7)O)NC(=O)[C@H](CC(=O)O)N
BoilingPoint
1555.4ºC at 760 mmHg
ShelfLife
>3 years if stored properly
Melting Point
N/A

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

Featured Services
Peptide CDMOPeptide Nucleic Acids SynthesisPeptide Synthesis ServicescGMP Peptide ServiceCustom Conjugation ServiceEpitope Mapping ServicesPeptide Modification ServicesPeptide Analysis Services
Hot Products
About us

Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.

From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.

Our Customers