Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist.
CAT No: R2071
CAS No:1239011-83-6
Synonyms/Alias:Mibenratide;Mibenratide [INN];mibenratida;1239011-83-6;UNII-P1T1143877;P1T1143877;JNJ-54452840;MIBENRATIDE [WHO-DD];mibenratidum;CHEMBL4297617;DTXSID501031265;DA-55466;Q27286014;Cyclo(L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-tyrosyl-L-asparaginyl-L-alpha-aspartyl-L-prolyl-L-lysyl-L-cysteinyl-L-seryl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-alanyl-L-alpha-aspartyl-L-alpha-glutamyl), cyclic (4-->10)-disulfide;
Chemical Name:3-[(1R,4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R,40S,43S,49S,52S,55S)-40-(4-aminobutyl)-52-(2-amino-2-oxoethyl)-22-(3-amino-3-oxopropyl)-28-benzyl-4,7-bis(3-carbamimidamidopropyl)-16,31,49-tris(carboxymethyl)-34-(hydroxymethyl)-55-[(4-hydroxyphenyl)methyl]-10,19-dimethyl-3,6,9,12,15,18,21,24,27,30,33,36,39,42,48,51,54,57-octadecaoxo-25-propan-2-yl-59,60-dithia-2,5,8,11,14,17,20,23,26,29,32,35,38,41,47,50,53,56-octadecazatricyclo[35.20.4.043,47]henhexacontan-13-yl]propanoic acid
Mibenratide is a synthetic peptide compound designed to modulate biological processes through specific interactions with cellular receptors and signaling pathways. As a structurally defined peptide, it is notable for its sequence-derived bioactivity and its capacity to mimic or influence endogenous peptide functions. Researchers value Mibenratide for its stability, reproducibility, and versatility in experimental systems, making it a valuable tool for probing peptide-mediated mechanisms in cellular and molecular biology. Its distinct biochemical profile enables controlled studies of peptide-receptor interactions, intracellular signaling cascades, and the modulation of physiological responses in vitro and in preclinical research settings.
Peptide signaling pathway research: Mibenratide serves as a reliable probe for investigating peptide signaling networks in various cell types. Its defined amino acid sequence allows researchers to dissect the roles of peptide ligands in receptor activation, downstream effector recruitment, and modulation of cellular responses. By integrating this peptide into receptor-binding assays or signal transduction studies, scientists can elucidate the specificity and kinetics of peptide-receptor interactions, advancing the understanding of fundamental biological communication processes.
Receptor binding studies: The compound is frequently utilized in quantitative receptor binding assays to characterize affinity, selectivity, and functional modulation of peptide-responsive receptors. Its synthetic nature ensures batch-to-batch consistency, which is critical for generating reproducible binding data. Such studies contribute to the mapping of receptor pharmacology, identification of novel ligand-binding domains, and the evaluation of structure-activity relationships within peptide-receptor systems.
Peptide structure-activity relationship (SAR) analysis: Mibenratide's well-defined sequence and modifiable structure make it an ideal candidate for SAR investigations. By introducing systematic modifications or analogs, researchers can assess the impact of specific amino acid residues on biological activity, stability, and receptor interaction. These insights are instrumental in designing next-generation peptide ligands with tailored functional properties for research applications.
Cellular response modulation: In vitro experiments often employ this peptide to modulate cellular responses, such as proliferation, differentiation, or apoptosis, in a controlled and reproducible manner. By applying Mibenratide to cultured cells, investigators can monitor downstream effects, dissect signaling pathways, and validate mechanistic hypotheses regarding peptide-mediated cellular regulation. Such studies provide a foundation for understanding how specific peptide signals orchestrate complex biological behaviors.
Peptide delivery and formulation research: The physicochemical properties of Mibenratide, including its solubility and stability, support its use in studies focused on peptide delivery systems and formulation optimization. Researchers may incorporate it into nanoparticle carriers, hydrogels, or other delivery vehicles to evaluate encapsulation efficiency, release kinetics, and bioactivity retention. These investigations are essential for developing advanced delivery strategies for peptide-based research tools and experimental therapeutics within laboratory settings.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
2. Myotropic activity of allatostatins in tenebrionid beetles
3. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
5. The spatiotemporal control of signalling and trafficking of the GLP-1R
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