Mifomelatide

Mifomelatide features a designed peptide backbone containing diverse functional groups that shape folding and molecular recognition. Its residue pattern supports investigations of structure-activity relationships and solvent-driven transitions. Researchers evaluate its stability, charge distribution, and binding behavior. Uses include peptide engineering, motif characterization, and advanced bioorganic studies.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Mifomelatide(CAS 1456699-27-6)

CAT No: R2508

CAS No:1456699-27-6

Synonyms/Alias:Mifomelatide;1456699-27-6;mifomelatide [INN];ZCH45RV64X;(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-N-[(2R)-1-[(2R)-2-carbamoylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-20-(naphthalen-2-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carboxamide;D-Prolinamide, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-prolyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysyl-D-valyl-, (2-->7)-lactam;

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M.F/Formula
C63H87N15O11
M.W/Mr.
1230.5
Sequence
One Letter Code:XDPXRWKVP
Three Letter Code:Ac-Nle-Asp(1)-Pro-D-2Nal-Arg-Trp-Lys(1)-D-Val-D-Pro-NH2

Mifomelatide is a synthetic peptide compound designed to modulate immune responses and has garnered significant attention for its unique structural properties and biological activity. Characterized by its ability to interact with specific cellular pathways, Mifomelatide is valued in research settings for its stability, solubility, and versatility in experimental applications. Its sequence allows for targeted investigation into immune modulation, making it a valuable tool for scientists seeking to understand complex biological processes. The compound's adaptability enables it to be incorporated into a wide range of in vitro and in vivo studies, supporting the advancement of knowledge in immunology and related fields. Researchers appreciate its reproducibility and the consistency of results obtained when using this peptide in controlled laboratory environments, further enhancing its reputation as a reliable research reagent.

Immunomodulation research: Mifomelatide is widely utilized in studies aiming to elucidate the mechanisms underlying immune system regulation. By modulating the activity of macrophages and other immune cells, the peptide offers researchers a means to dissect signaling pathways and cellular responses involved in inflammation and host defense. Its ability to influence cytokine production and cellular activation makes it a preferred choice in experiments designed to characterize immune cell behavior under various stimuli. Scientists leverage Mifomelatide's properties to investigate the balance between pro-inflammatory and anti-inflammatory responses, which is critical in understanding autoimmune conditions, infection models, and the development of novel immunotherapeutic strategies.

Inflammatory pathway analysis: The peptide serves as a powerful tool in the exploration of molecular mechanisms governing inflammation. Researchers employ Mifomelatide to probe the activation and inhibition of key signaling molecules, such as NF-κB and MAPKs, within cellular models of inflammation. By analyzing changes in gene expression and protein phosphorylation following treatment, investigators gain insights into the cascade of events that drive inflammatory responses. This application is particularly valuable in identifying potential molecular targets for the development of anti-inflammatory agents and in advancing the understanding of chronic inflammatory diseases at a cellular level.

Innate immunity studies: Mifomelatide is instrumental in experiments focused on the innate immune system, providing a means to assess the activation of pattern recognition receptors and the subsequent production of mediators like nitric oxide and reactive oxygen species. Its use in macrophage and dendritic cell models allows researchers to monitor the initial events of the immune response, mapping the interactions between innate immune cells and their microenvironment. Such studies contribute to a more comprehensive understanding of host-pathogen interactions, the resolution of inflammation, and the mechanisms underlying immune surveillance.

Drug discovery and screening: The peptide's defined activity profile makes it an ideal candidate for high-throughput screening assays aiming to identify new modulators of immune function. Pharmaceutical researchers incorporate Mifomelatide into cell-based assays to evaluate the efficacy of small molecules, peptides, or biologics in modulating immune responses. Its predictable effects on immune cells provide a consistent baseline for comparative studies, facilitating the identification of compounds with desirable immunomodulatory properties. This application accelerates the drug discovery process by enabling rapid and reproducible assessment of candidate therapeutics in preclinical research.

Biomarker development: In the context of translational research, Mifomelatide is employed to validate and characterize biomarkers associated with immune activation and inflammation. By serving as a reference compound in experimental workflows, it aids in the identification and quantification of molecular signatures indicative of immune status. Researchers utilize the peptide to calibrate assays and to benchmark the performance of diagnostic tools, thereby supporting the development of more accurate and sensitive methods for monitoring immune responses in various disease models. The ability to reliably induce or modulate specific immune parameters underscores its value in the ongoing search for robust biomarkers in biomedical research.

Overall, Mifomelatide stands out as a multifaceted research tool with broad applications in immunology, inflammation, innate immunity, drug discovery, and biomarker development. Its unique properties enable scientists to dissect complex biological processes, identify novel therapeutic targets, and enhance the precision of experimental approaches. As the scientific community continues to explore the intricacies of immune regulation and disease pathogenesis, Mifomelatide remains an indispensable asset in the advancement of biomedical research and the pursuit of innovative solutions to pressing health challenges.

InChI
InChI=1S/C63H87N15O11/c1-5-6-19-44(70-37(4)79)55(82)75-49-34-52(80)67-27-12-11-21-45(57(84)76-53(36(2)3)62(89)77-29-14-23-50(77)54(64)81)71-59(86)48(33-41-35-69-43-20-10-9-18-42(41)43)73-56(83)46(22-13-28-68-63(65)66)72-58(85)47(74-60(87)51-24-15-30-78(51)61(49)88)32-38-25-26-39-16-7-8-17-40(39)31-38/h7-10,16-18,20,25-26,31,35-36,44-51,53,69H,5-6,11-15,19,21-24,27-30,32-34H2,1-4H3,(H2,64,81)(H,67,80)(H,70,79)(H,71,86)(H,72,85)(H,73,83)(H,74,87)(H,75,82)(H,76,84)(H4,65,66,68)/t44-,45-,46-,47+,48-,49-,50+,51-,53+/m0/s1
InChI Key
MBDALAXLRYJVAO-AXWWBJHISA-N

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