Mifomelatide features a designed peptide backbone containing diverse functional groups that shape folding and molecular recognition. Its residue pattern supports investigations of structure-activity relationships and solvent-driven transitions. Researchers evaluate its stability, charge distribution, and binding behavior. Uses include peptide engineering, motif characterization, and advanced bioorganic studies.
CAT No: R2508
CAS No:1456699-27-6
Synonyms/Alias:Mifomelatide;1456699-27-6;mifomelatide [INN];ZCH45RV64X;(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-N-[(2R)-1-[(2R)-2-carbamoylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-20-(naphthalen-2-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carboxamide;D-Prolinamide, N-acetyl-L-norleucyl-L-alpha-aspartyl-L-prolyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysyl-D-valyl-, (2-->7)-lactam;
Mifomelatide is a synthetic peptide compound known for its immunomodulatory properties and its role as a macrophage-activating factor. As a structurally defined peptide, it is derived from the N-terminal sequence of human tuftsin and is recognized for its ability to influence various immune system pathways. Mifomelatide has attracted significant interest in biochemical and immunological research due to its capacity to modulate cellular responses, making it a valuable tool for investigations into innate immunity, macrophage function, and peptide-mediated signal transduction. Its unique structure and biological activity position it as a relevant reagent for exploring peptide-based mechanisms and for developing advanced immunological assays.
Immunological research: Mifomelatide serves as a robust model compound for studying macrophage activation and innate immune modulation. Researchers employ it to evaluate how specific peptide motifs interact with immune cells, particularly in the context of cytokine production, phagocytosis, and antigen presentation. Its well-characterized activity provides a platform for dissecting the molecular pathways involved in host defense and inflammation, facilitating the identification of novel targets for immunological intervention and the understanding of peptide-driven cell signaling.
Peptide functional studies: The synthetic peptide is widely used in experimental systems to elucidate the structure-activity relationships of immunomodulatory peptides. By analyzing the biological responses induced by mifomelatide, scientists can gain insight into the critical sequence determinants required for macrophage stimulation and receptor engagement. Such studies are instrumental in guiding the rational design of new peptide analogs with tailored biological functions and in expanding the repertoire of bioactive peptides for research applications.
Cellular signaling pathway analysis: Mifomelatide is a valuable reagent for probing intracellular signaling mechanisms in immune cells. Its ability to activate macrophages enables detailed examination of downstream signaling cascades, such as the activation of NF-κB, MAPK, and other transcriptional regulators. These investigations help clarify how peptide ligands transduce extracellular signals into functional cellular outcomes, thereby advancing understanding of immune cell regulation and the broader landscape of peptide-mediated communication.
In vitro assay development: The defined activity profile of mifomelatide makes it an excellent standard or positive control in the development and optimization of in vitro assays targeting macrophage function. Researchers utilize it to benchmark assay sensitivity, validate detection platforms, and calibrate experimental conditions for measuring immune cell activation. Its reproducible effects contribute to assay reliability and facilitate the comparison of results across different experimental systems and laboratories.
Peptide synthesis and analytical validation: As a reference peptide, mifomelatide is often incorporated into quality control protocols for peptide synthesis and analytical method development. Its well-established sequence and bioactivity make it suitable for validating synthetic strategies, chromatographic methods, and bioassays used in peptide research. Employing mifomelatide as a standard supports rigorous quality assurance processes and ensures the accuracy and reproducibility of peptide-based experimental workflows.
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