Nangibotide is an inhibitor of TREM-1, a receptor found on certain white blood cells.
CAT No: R2070
CAS No:2014384-91-7
Synonyms/Alias:Nangibotide;2014384-91-7;nangibotidum;Nangibotida;DTXSID201336482;Motrem;NANGIBOTIDE [INN];59HD7BLX9H;NANGIBOTIDE [WHO-DD];DTXCID101766688;Lissamine-rhodamine dodecanoic acid;LR 12;LR-12;DA-65927;Leu-Gln-Glu-Glu-Asp-Ala-Gly-Glu-Tyr-Gly-Cys-Met-NH2;L-METHIONINAMIDE, L-LEUCYL-L-GLUTAMINYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-ASPARTYL-L-ALANYLGLYCYL-L-.ALPHA.-GLUTAMYL-L-TYROSYLGLYCYL-L-CYSTEINYL-;L-Methioninamide, L-leucyl-L-glutaminyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alanylglycyl-L-alpha-glutamyl-L-tyrosylglycyl-L-cysteinyl-;
Chemical Name:(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[2-[[(2R)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Nangibotide is a synthetic peptide compound designed to interact with the TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) pathway, an important modulator of innate immune responses. As a peptide-based antagonist, Nangibotide specifically targets and inhibits the signaling cascade initiated by TREM-1 activation, which is implicated in the amplification of inflammatory responses. Its unique mode of action and high specificity make it a valuable tool for dissecting the molecular mechanisms underlying immune regulation and inflammation in various experimental systems. Researchers interested in immunology, cell signaling, and peptide-receptor interactions frequently leverage Nangibotide for its ability to modulate key pathways relevant to both basic and applied biochemical investigations.
Immunology research: Nangibotide serves as a critical reagent for studies focused on the regulation of innate immunity, particularly those investigating the TREM-1 signaling axis. By selectively blocking TREM-1-mediated activation of myeloid cells, it enables researchers to elucidate the downstream effects of TREM-1 engagement in models of acute and chronic inflammation. Such studies are instrumental in mapping the contribution of TREM-1 to cytokine release, leukocyte recruitment, and the overall orchestration of immune responses.
Inflammatory pathway analysis: The peptide is widely utilized in experiments aimed at dissecting the molecular events that drive excessive inflammatory signaling. By acting as a competitive inhibitor, Nangibotide allows for precise modulation of TREM-1 activity in vitro and in vivo, facilitating the identification of downstream signaling molecules and transcriptional targets. This application is particularly valuable in differentiating TREM-1-dependent processes from parallel inflammatory pathways, providing clarity in complex models of immune activation.
Peptide-receptor interaction studies: Nangibotide is frequently employed in structural and functional analyses of peptide-receptor binding. Its well-characterized sequence and defined binding properties make it an ideal probe for affinity assays, receptor mapping, and kinetic studies. Researchers can use it to quantify binding affinities, determine receptor occupancy, and explore structure-activity relationships, thereby advancing the understanding of peptide-based modulation of immune receptors.
Biomarker discovery: The compound's ability to modulate TREM-1 signaling positions it as a valuable tool for identifying novel biomarkers associated with immune activation and inflammation. By altering the cellular response to inflammatory stimuli, Nangibotide can help reveal gene expression signatures, secreted factors, or cell surface markers that are specifically regulated through the TREM-1 axis. Such insights are crucial for advancing biomarker-driven approaches in immunological research.
Preclinical model development: In the context of experimental disease modeling, Nangibotide is used to validate the role of TREM-1 in various pathophysiological processes. By administering the peptide in animal or cell-based models, researchers can assess the impact of TREM-1 blockade on disease progression, tissue injury, and immune cell dynamics. These studies provide foundational data for the development of targeted interventions and contribute to a deeper understanding of immune modulation in preclinical research settings.
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