Neurokinin A

Neurokinin A is an endogenous tachykinin agonist with preference for the NK-2R

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Neurokinin A(CAS 86933-74-6)

CAT No: 10-101-295

CAS No:86933-74-6

Synonyms/Alias:NEUROKININ A;86933-74-6;Neurokinin alpha;Substance K;Neuromedin L;Neurokinin A (alligator);Porcine neurokinin A;Neurokinin A (Python molurus);Neurokinin alpha (porcine);Neurokinin A (pig spinal cord);Neuromedin L (pig spinal cord);Neurokinin A (swine spinal cord);Neurokinin alpha (pig spinal cord);94168F9W1D;CHEMBL217406;Neurokinin A trifluoroacetate salt;DTXSID701027125;Kassinin, 1-de-L-aspartic acid-2-de-L-valine-3-L-histidine-5-L-threonine-7-L-serine-;His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2;L-Methioninamide, L-histidyl-L-lysyl-L-threonyl-L-alpha-aspartyl-L-seryl-L-phenylalanyl-L-valylglycyl-L-leucyl-;(5S,8S,14S,17S,20S,23S)-23-((2S,3R)-2-((S)-6-amino-2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)hexanamido)-3-hydroxybutanamido)-17-benzyl-5-carbamoyl-20-(hydroxymethyl)-8-isobutyl-14-isopropyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid;L-HISTIDYL-L-LYSYL-L-THREONYL-L-.ALPHA.-ASPARTYL-L-SERYL-L-PHENYLALANYL-L-VALYLGLYCYL-L-LEUCYL-L-METHIONINAMIDE;L-METHIONINAMIDE, L-HISTIDYL-L-LYSYL-L-THREONYL-L-.ALPHA.-ASPARTYL-L-SERYL-L-PHENYLALANYL-L-VALYLGLYCYL-L-LEUCYL-;NKA;[125I]-neurokinin A;GTPL2089;GTPL3795;UNII-94168F9W1D;[125I]-NKA;DTXCID501511356;[125I]NKA (human, mouse, rat);BDBM50001447;-Neurokinin;Neuromedin L;Substance K;AKOS024456420;AKOS040763868;DA-76125;FN109083;TS-10268;G12445;His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2);His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(NeurokininA);H-His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2; H-HKTDSFVGLM-NH2;(3S)-3-[(2S,3R)-2-[(2S)-6-AMINO-2-[(2S)-2-AMINO-3-(1H-IMIDAZOL-4-YL)PROPANAMIDO]HEXANAMIDO]-3-HYDROXYBUTANAMIDO]-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-CARBAMOYL-3-(METHYLSULFANYL)PROPYL]CARBAMOYL}-3-METHYLBUTYL]CARBAMOYL}METHYL)CARBAMOYL]-2-METHYLPROPYL]CARBAMOYL}-2-PHENYLETHYL]CARBAMOYL}-2-HYDROXYETHYL]CARBAMOYL}PROPANOIC ACID;L-HISTIDYL-L-LYSYL-L-THREONYL-L-ALPHA-ASPARTYL-L-SERYL-L-PHENYLALANYL-L-VALYLGLYCYL-L-LEUCYL-L-METHIONINAMIDE;

Chemical Name:(3S)-3-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C50H80N14O14S
M.W/Mr.
1133.3
Sequence
One Letter Code:HKTDSFVGLM
Three Letter Code:H-His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Appearance
Powder
Purity
≥97% (HPLC)
Activity
Antibacterial, Antifungal
Length
10
Long-term Storage Conditions
Soluble to 1 mg/ml in water
Shipping Condition
Wet ice in continental US; may vary elsewhere
InChI
InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1
InChI Key
HEAUFJZALFKPBA-JPQUDPSNSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N
Isomeric SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CN=CN2)N)O

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