Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.
CAT No: R1534
CAS No:86933-75-7
Synonyms/Alias:Neurokinin B;86933-75-7;Neuromedin K;NEUROKININ K;Neurokinin beta;Tachykinin-3;CHEMBL437797;DTXSID4040890;CHEBI:80312;Neurokinin B trifluoroacetate salt;Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2;NKB;GTPL2090;Kassinin, 2-L-methionine-3-L-histidine-4-de-L-lysine-5-de-L-serine-7-L-phenylalanine-;DTXCID301473984;BDBM50079412;AKOS024456682;AS-83342;DA-76127;FN108584;G91081;SR-05000014260;SR-05000014260-1;(NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2;Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2(Neurokinin B);H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2; H-DMHDFFVGLM-NH2;
Neurokinin B is a member of the tachykinin peptide family, characterized by its decapeptide structure and its role as a potent endogenous ligand for the neurokinin-3 (NK3) receptor. As a key neuropeptide, it is widely recognized for its involvement in modulating neurotransmission, neuroendocrine signaling, and various central and peripheral physiological processes. Its presence in the central nervous system, particularly within the hypothalamus, underscores its significance in neurobiological research, where it is frequently studied for its regulatory effects on reproductive function, stress responses, and synaptic communication. The availability of high-quality synthetic Neurokinin B enables researchers to dissect its molecular mechanisms and functional impact in diverse experimental models.
Receptor pharmacology: Neurokinin B is extensively used in receptor binding studies and functional assays aimed at elucidating the pharmacological properties of NK3 receptors. By serving as a selective agonist, it allows for precise characterization of receptor-ligand interactions, signal transduction pathways, and receptor subtype specificity. These investigations are fundamental for advancing the understanding of tachykinin receptor biology and for supporting the development of novel NK3-targeted modulators in basic research contexts.
Neuroendocrine research: The peptide is a critical tool for exploring the regulation of gonadotropin-releasing hormone (GnRH) secretion and broader hypothalamic-pituitary-gonadal (HPG) axis dynamics. Experimental application of Neurokinin B in hypothalamic explants, primary neuronal cultures, or animal models enables detailed analysis of its role in modulating reproductive hormone release, pulse generation, and feedback regulation. These studies provide valuable insights into the neuroendocrine control of fertility, puberty, and reproductive cyclicity.
Neuroscience investigations: Researchers utilize Neurokinin B to probe the mechanisms of synaptic transmission and neuronal excitability within specific brain regions. Its ability to modulate neurotransmitter release, influence neuronal firing rates, and interact with other neuropeptide systems makes it a versatile tool for dissecting neural circuits underlying behavior, sensory processing, and homeostatic regulation. Applications in electrophysiological recordings and neuroanatomical mapping further enhance the understanding of tachykininergic signaling pathways.
Peptide signaling pathway studies: The synthetic form of this peptide supports detailed investigations into intracellular signaling cascades activated by NK3 receptor engagement. By applying Neurokinin B to cultured cells or tissue preparations, researchers can monitor downstream events such as calcium mobilization, kinase activation, and gene expression modulation. These studies are essential for clarifying the molecular basis of tachykinin-mediated responses and for identifying potential regulatory nodes within complex signaling networks.
Peptide synthesis and assay development: Neurokinin B serves as a reference standard and functional control in the development and validation of peptide-based assays, including immunoassays and receptor activity screens. Its well-characterized sequence and biological activity make it an indispensable reagent for optimizing analytical protocols, calibrating detection systems, and benchmarking assay sensitivity and specificity in both academic and industrial research laboratories.
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