Novexatin (NP213)

Name: Novexatin (NP213)
Brand: Creative Peptides
SKU: R1890
Availability: MadeToOrder

Novexatin (NP213) is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections.

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CAT No: R1890

CAS No: 942577-31-3

Synonyms/Alias: Novexatin;942577-31-3;NP213;2-[3-[(2S,5S,8S,11S,14S,17S,20S)-5,8,11,14,17,20-hexakis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptazacyclohenicos-2-yl]propyl]guanidine;CHEMBL2203696;SCHEMBL19712180;EX-A7462;AKOS040764209;DA-76279;HY-126810;CS-0107537;1,1',1'',1''',1'''',1''''',1''''''-(((2S,5S,8S,11S,14S,17S,20S)-3,6,9,12,15,18,21-Heptaoxo-1,4,7,10,13,16,19-heptaazacyclohenicosane-2,5,8,11,14,17,20-heptayl)heptakis(propane-3,1-diyl))heptaguanidine;

Chemical Name: 2-[3-[(2S,5S,8S,11S,14S,17S,20S)-5,8,11,14,17,20-hexakis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptazacyclohenicos-2-yl]propyl]guanidine

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C42H84N28O7
M.W/Mr.	1093.3
Sequence	Three Letter Code:cyclo[Arg-Arg-Arg-Arg-Arg-Arg-Arg]
Appearance	Solid powder
Purity	>98%

Long-term Storage Conditions	10 mM in DMSO
Shipping Condition	RT, or blue ice upon request.
InChI	InChI=1S/C42H84N28O7/c43-36(44)57-15-1-8-22-29(71)65-24(10-3-17-59-38(47)48)31(73)67-26(12-5-19-61-40(51)52)33(75)69-28(14-7-21-63-42(55)56)35(77)70-27(13-6-20-62-41(53)54)34(76)68-25(11-4-18-60-39(49)50)32(74)66-23(30(72)64-22)9-2-16-58-37(45)46/h22-28H,1-21H2,(H,64,72)(H,65,71)(H,66,74)(H,67,73)(H,68,76)(H,69,75)(H,70,77)(H4,43,44,57)(H4,45,46,58)(H4,47,48,59)(H4,49,50,60)(H4,51,52,61)(H4,53,54,62)(H4,55,56,63)/t22-,23-,24-,25-,26-,27-,28-/m0/s1
InChI Key	NVZLKNHDHPPJHL-RMIXPHLWSA-N
Canonical SMILES	N/C(N)=N\CCC[C@@H](C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@H]1CCC/N=C(N)\N)=O)=O)=O)=O)=O)=O)NC1=O

1. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

2. An Isolated TCR αβ Restricted by HLA-A* 02: 01/CT37 Peptide Redirecting CD8+ T Cells to Kill and Secrete IFN-γ in Response to Lung Adenocarcinoma Cell Lines

3. High fat diet and GLP-1 drugs induce pancreatic injury in mice

4. Cationic cell-penetrating peptides are potent furin inhibitors

5. The spatiotemporal control of signalling and trafficking of the GLP-1R

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