O-tert.Butyl-D-tyrosine

O-tert.Butyl-D-tyrosine is a D-configured tyrosine derivative in which the phenolic hydroxyl of the tyrosine side chain is O-alkylated with a tert-butyl group, retaining the aromatic ring and the amino acid backbone. The molecule contains a free amino group and a carboxyl group on the α-carbon, while the side chain bears a tert-butyl-protected phenol that reduces phenolic hydrogen-bonding and masks the phenolic nucleophile. O-tert.Butyl-D-tyrosine is used as a protected amino acid building block in peptide-related synthesis and structure-activity studies where controlled handling of the tyrosine phenol is required, including preparation of tyrosine-containing peptide intermediates and analytical standards for derivatization workflows.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP02135

CAS No:186698-58-8

Synonyms/Alias:186698-58-8;(R)-2-Amino-3-(4-(tert-butoxy)phenyl)propanoicacid;H-D-Tyr(tBu)-OH;O-tert-Butyl-D-tyrosine;AmbotzHAA7290;O-t-butyl-D-tyrosine;AC1OLQYK;O-tert.Butyl-D-tyrosine;D-TyrosineO-T-butylether;SCHEMBL2867832;CTK3J1759;MolPort-008-268-078;SNZIFNXFAFKRKT-LLVKDONJSA-N;ZINC4899542;AM82339;RTR-008628;AJ-52564;AK111179;KB-59334;TR-008628;ST24035311;K-5613;I01-7262;(2R)-2-amino-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoicacid

Custom Peptide Synthesis

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C13H19NO3

M.W/Mr.

237.3

Abbr

H-D-Tyr (tBu)-OH

InChI

1S/C13H19NO3/c1-13(2,3)17-10-6-4-9(5-7-10)8-11(14)12(15)16/h4-7,11H,8,14H2,1-3H3,(H,15,16)/t11-/m1/s1

InChI Key

SNZIFNXFAFKRKT-LLVKDONJSA-N

Canonical SMILES

CC(C)(C)OC1=CC=C(C=C1)CC(C(=O)O)N

1. Therapeutic potential of an intestinotrophic hormone, glucagon-like peptide 2, for treatment of type 2 short bowel syndrome rats with intestinal bacterial and fungal dysbiosis

2. P-selectin and Complement’s Role in a Neonatal Model of Germinal Matrix Hemorrhage-Induced Secondary Injury

3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate

4. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

5. The spatiotemporal control of signalling and trafficking of the GLP-1R

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

Featured Services

Epitope Mapping Services Custom Conjugation Service Peptide Modification Services Peptide Nucleic Acids Synthesis Peptide CDMO cGMP Peptide Service Peptide Analysis Services Peptide Synthesis Services

Hot Products

Teriparatide Acetate

Teriparatide Acetate is a bone-forming peptide supporting osteoporosis research. Buy Teriparatide peptide online to study bone growth and calcium metabolism.

Read More

Buserelin Acetate

Buserelin Acetate is a GnRH agonist peptide regulating reproductive hormones. Buy Buserelin peptide powder online to explore fertility and hormone-dependent tumor research.

Read More

Deslorelin peptide is a potent GnRH agonist used for fertility and hormonal control. Buy Deslorelin peptide powder online for veterinary and endocrine research applications.

Read More

Argipressin peptide regulates water balance and blood pressure in biological systems. Shop pure Argipressin peptide online for cardiovascular and kidney research.

Read More

Angiotensin II Acetate

Angiotensin II Acetate is a potent research peptide regulating blood pressure and vascular tone. Purchase this synthetic peptide to support cardiovascular and renal studies.

Read More

Atosiban is a peptide oxytocin receptor antagonist that helps prevent preterm labor. Buy Atosiban peptide for reproductive and uterine contractility research.

Read More

Gonadorelin Acetate

Gonadorelin Acetate stimulates LH and FSH release in fertility research. Purchase Gonadorelin peptide powder from a verified peptide supplier for reproductive studies.

Read More

Fertirelin Acetate

Fertirelin Acetate is a synthetic peptide that promotes ovulation and fertility. Purchase Fertirelin research peptide for breeding and hormonal studies.

Read More

Thymosin β4 Acetate

Thymosin β4 Acetate promotes wound healing, tissue repair, and cell regeneration. Buy Thymosin beta 4 peptide powder for research on recovery and regenerative medicine.

Read More

DOTA-cyclo(RGDfK) acetate

DOTA-cyclo(RGDfK) acetate is a metal-chelating cyclic RGD peptide used to investigate integrin-binding motifs. Its cyclized structure stabilizes ligand presentation for receptor-targeting studies. Researchers analyze its conformation for high-affinity binding models. The DOTA moiety supports imaging-related biochemical experiments.

Read More

About us

Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.

From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.

Our Customers