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O-tert.Butyl-trans-4-hydroxy-L-proline

O-tert.Butyl-trans-4-hydroxy-L-proline is a protected proline derivative in which the 4-hydroxy group is O-alkylated as an O-tert-butyl ether, retaining the proline ring system and the trans relationship indicated in the name while specifying the L stereochemical form. The molecule contains a secondary amine and a carboxyl functional group on the proline backbone, with the side-chain hydroxyl functionality masked as a tert-butyl ether to modulate polarity and chemoselectivity during synthesis. As a stepwise peptide-synthesis building block or structural analog, it can be employed to control protection of the hydroxy group while introducing a hydroxyl-bearing proline motif for studies involving peptide structure, conformational effects, or subsequent deprotection to regenerate the free 4-hydroxyl group.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP01114

CAS No:79775-07-8

Synonyms/Alias:H-Hyp(tBu)-OH;79775-07-8;trans-4-(tert-Butoxy)pyrrolidine-2-carboxylicacid;AC1OLR3E;AC1Q1MP4;4beta-tert-Butoxy-L-proline;SCHEMBL2145830;MolPort-008-266-668;ZINC4899586;(2S,4R)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylicAcid;CH-536;KM1995;AKOS006274931;AM81838;O-tert.Butyl-trans-4-hydroxy-L-proline;AJ-52572;AK111190;FT-0080717;ST24050205

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M.F/Formula
C9H17NO3
M.W/Mr.
187.3
Abbr
H-Hyp(tBu)-OH
InChI
1S/C9H17NO3/c1-9(2,3)13-6-4-7(8(11)12)10-5-6/h6-7,10H,4-5H2,1-3H3,(H,11,12)/t6-,7+/m1/s1
InChI Key
XTQZONYRNXFGCY-RQJHMYQMSA-N
Canonical SMILES
CC(C)(C)OC1CC(NC1)C(=O)O

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