Palmitoyl tripeptide-5 triflate is a component of cell transduction, and promotes the production of collagen. It is commonly used in anti-aging and anti-wrinkle cosmetic
CAT No: R1815
CAS No:623172-56-5
Synonyms/Alias:Palmitoyl Tripeptide-5;palmitoyl-lysyl-valyl-lysine;SYN-COLL;2A3916MQHO;L-Lysine, N2-(1-oxohexadecyl)-L-lysyl-L-valyl-;623172-55-4;Pal-Lys-Val-Lys;SCHEMBL443317;HY-P5250;PALMITOYL TRIPEPTIDE-5 [INCI];PD124663;CS-0863858;Q27254465;(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid;
Palmitoyl Tripeptide-5 is a synthetic peptide compound composed of three amino acids conjugated with a palmitoyl group, designed to enhance stability and bioavailability in various biochemical contexts. As a member of the signal peptide family, it exhibits unique properties that make it valuable in studies of peptide-cell interactions, signal transduction, and extracellular matrix modulation. Its amphiphilic nature facilitates membrane association, rendering it a favored tool in research focused on cellular communication and peptide-based functional assays. Due to its tailored structure, Palmitoyl Tripeptide-5 is frequently explored for its role in modulating protein synthesis and influencing key cellular pathways, making it a versatile asset in peptide research and development.
Peptide signaling pathway research: Palmitoyl Tripeptide-5 is widely utilized in investigations that dissect peptide-mediated signaling mechanisms, particularly those involving collagen synthesis and fibroblast activation. Researchers leverage its ability to interact with cell surface receptors and modulate downstream pathways, providing insights into the regulation of extracellular matrix components. Its defined sequence and lipid modification allow for precise experimental manipulation, enabling the study of structure-activity relationships in peptide signaling and the identification of potential molecular targets involved in tissue remodeling and cellular differentiation.
Peptide synthesis and assay development: The compound serves as a reference standard and functional component in the synthesis of modified peptides for analytical and screening applications. Its palmitoylation enhances peptide stability and membrane affinity, making it a model substrate for evaluating the impact of lipid modifications on peptide function. In assay development, Palmitoyl Tripeptide-5 is employed to calibrate detection systems or to validate the performance of analytical platforms designed to detect or quantify bioactive peptides in complex matrices.
Extracellular matrix modulation studies: Due to its structural similarity to naturally occurring signaling peptides, Palmitoyl Tripeptide-5 is frequently incorporated into experimental models that examine the regulation of extracellular matrix components such as collagen, elastin, and glycoproteins. By modulating cellular responses associated with matrix synthesis or degradation, it provides a controlled means to investigate the molecular mechanisms underlying tissue homeostasis, wound healing, and fibrosis. These studies are essential for elucidating the roles of bioactive peptides in maintaining structural integrity and function in various biological systems.
Cell culture and in vitro modeling: In cell-based assays, Palmitoyl Tripeptide-5 is applied to cultured fibroblasts, keratinocytes, or other relevant cell types to assess its influence on gene expression, protein production, and cell behavior. Its defined activity profile enables researchers to model specific aspects of cell-matrix interactions, signal transduction, and peptide uptake. This application supports the development of robust in vitro systems for studying peptide efficacy, cellular responses to extracellular cues, and the optimization of peptide delivery strategies.
Peptide-protein interaction analysis: The compound is also employed in biophysical and biochemical studies aimed at characterizing peptide-protein interactions. Its stable, palmitoylated structure facilitates binding assays, structural elucidation, and kinetic analyses, contributing to a deeper understanding of the molecular interfaces governing peptide recognition and function. Such investigations aid in the rational design of novel peptide analogs with tailored biological activities and inform the development of advanced peptide-based research tools.
1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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