Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
CAT No: R1909
CAS No:1541011-97-5
Synonyms/Alias:pep 2-8;Pep2-8;1541011-97-5;TVFTSWEEYLDWV;Ac-TVFTSWEEYLDWV-NH2;CHEMBL4226740;BDBM217366;HY-P2276;PEP2-8 TRIFLUOROACETATE SALT;AKOS034831586;PP43056;DA-76720;MS-32219;CS-0121063;
Chemical Name:(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Pep 2-8 is a synthetic peptide compound designed for advanced biochemical and molecular biology research. As a short-chain peptide, it is engineered to mimic or disrupt specific protein-protein interactions, making it an essential tool for probing cellular signaling pathways and elucidating the functional roles of peptide motifs within biological systems. Its defined amino acid sequence and structural properties enable researchers to study mechanisms of molecular recognition, receptor binding, and downstream signaling events. The versatility and specificity of Pep 2-8 have positioned it as a valuable reagent in peptide-based investigations across a range of scientific disciplines.
Signal transduction research: Pep 2-8 is frequently employed in studies focused on dissecting intracellular signaling cascades. By acting as a competitive inhibitor or functional mimic of endogenous protein segments, it facilitates the analysis of key regulatory nodes within pathways such as kinase activation, receptor-ligand interactions, or adaptor protein recruitment. Researchers use it to map binding domains, quantify affinity constants, and assess the contribution of discrete peptide sequences to the modulation of cellular responses.
Protein-protein interaction mapping: The peptide serves as a precise molecular probe for characterizing transient or stable associations between proteins. Its application in pull-down assays, surface plasmon resonance (SPR), and co-immunoprecipitation experiments enables the identification of binding partners and the delineation of interaction interfaces. This approach aids in unraveling the structural determinants of specificity and affinity, providing critical insights into the assembly of multi-protein complexes and the regulation of cellular machinery.
Peptide structure-function analysis: Pep 2-8 is widely utilized in systematic mutagenesis and alanine-scanning experiments to investigate the functional relevance of individual amino acid residues within a peptide sequence. By introducing targeted modifications, researchers can assess the impact on biological activity, stability, and receptor engagement. Such studies are instrumental in defining minimal active motifs and optimizing peptide leads for subsequent research applications.
Cellular uptake and delivery studies: Due to its manageable size and customizable sequence, the peptide is often incorporated into model systems to evaluate mechanisms of cellular internalization and intracellular trafficking. It is used to test the efficacy of various delivery vectors, assess endosomal escape, and explore the influence of sequence modifications on membrane permeability. These investigations support the rational design of peptide-based delivery platforms for intracellular targeting in fundamental research settings.
Analytical and assay development: Pep 2-8 is integral to the development and validation of peptide-based analytical assays, including enzyme-linked immunosorbent assays (ELISA), mass spectrometry-based quantification, and biosensor platforms. Its consistent composition and defined reactivity make it a reliable standard for calibrating detection systems, optimizing assay sensitivity, and benchmarking experimental reproducibility. This utility underpins its widespread adoption in laboratory workflows that demand high specificity and quantitative precision.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More