Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
CAT No: R1609
CAS No:106362-32-7
Synonyms/Alias:PEPTIDE T;106362-32-7;peptide-t;UNII-05DYM3ZS1X;05DYM3ZS1X;HIV Peptide T;Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr;L-Threonine,L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;PEPTIDE T [MI];l-alanyl-l-seryl-l-threonyl-l-threonyl-l-threonyl-l-asparaginyl-l-tyrosyl-l-threonine;(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acid;H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH;L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-;UNII-YM99OI1N73;Peptide T, HIV;ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE;CHEMBL180971;SCHEMBL5813760;L-Threonine, N-(N-(N2-(N-(N-(N-(N-D-alanyl-L-seryl)-L-threonyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-;NCGC00167163-01;DB-230568;G12253;Q7166522;L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;L-THREONINE, L-ALANYL-L-SERYL-L-THREONYL-L-THREONYL-L- THREONYL-L-ASPARAGINYL-L-TYROSYL-;
Peptide T is a synthetic octapeptide that has garnered significant interest within the biochemical and molecular research communities due to its unique structural properties and its ability to interact with specific cellular receptors. As a short-chain peptide, it is characterized by a defined amino acid sequence that enables selective binding and modulation of certain protein targets. Its relevance extends to studies investigating peptide-receptor interactions, cell signaling mechanisms, and the broader understanding of peptide-based modulators in biological systems. Peptide T's functional significance is further underscored by its use as a molecular tool in probing receptor specificity and elucidating the dynamics of peptide-mediated cellular processes.
Receptor binding studies: Researchers utilize Peptide T to investigate the binding affinity and specificity of peptides for chemokine receptors, particularly those belonging to the G protein-coupled receptor family. By serving as a reference ligand or competitive inhibitor in binding assays, it facilitates the characterization of receptor-ligand interactions, aiding in the mapping of critical binding domains and the identification of structural determinants that govern receptor selectivity. These studies are foundational for understanding the molecular basis of peptide recognition and signaling in various physiological and pathophysiological contexts.
Cell signaling pathway analysis: The compound is frequently employed in experiments designed to elucidate downstream signaling events triggered by peptide-receptor engagement. Through the application of Peptide T in cell-based assays, researchers can monitor changes in intracellular signaling cascades, such as alterations in second messenger levels, kinase activation, or transcriptional responses. This approach enables the dissection of specific pathways activated or inhibited by peptide interaction, providing valuable insights into the regulatory networks that control cellular function and response to external stimuli.
Peptide structure-activity relationship (SAR) research: Peptide T serves as a model system for investigating the relationship between peptide sequence, conformation, and biological activity. By systematically modifying its amino acid residues or backbone, scientists can assess the impact of structural changes on receptor binding, stability, and functional efficacy. These SAR studies are critical for advancing the rational design of novel peptides with enhanced properties, such as improved selectivity, stability, or bioactivity, which are essential for both basic research and the development of peptide-based tools.
Analytical method development: In analytical biochemistry, Peptide T is used as a well-defined reference standard for the calibration and validation of peptide detection methods. Techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis benefit from its consistent physicochemical properties, enabling accurate quantification and characterization of peptide samples. Its application in method development supports the establishment of robust analytical protocols for peptide identification, purity assessment, and quality control in research laboratories.
Peptide-based functional assays: The compound is also incorporated into functional assays to evaluate the biological consequences of peptide-receptor interactions. In these settings, it is used to probe receptor-mediated cellular responses, such as chemotaxis, calcium flux, or gene expression changes. By providing a defined and reproducible stimulus, Peptide T enables the assessment of receptor function, the screening of potential modulators, and the validation of assay systems designed to monitor peptide-induced cellular effects. This application is particularly valuable in high-throughput screening and mechanistic studies aimed at dissecting the functional roles of peptide ligands in cell biology.
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