PGLU-HIS-PRO Amide Acetate Salt is a peptide-based compound composed of the amino acids Proline, Glycine, Leucine, Histidine, and Proline. It is a salt form of the amide acetate, which is a derivative of acetic acid. This compound is used in research and development for various applications, including drug delivery, protein engineering, and bioconjugation. It is also used in the production of peptide-based drugs and other pharmaceuticals.
CAT No: 10-101-209
CAS No:40216-95-3
Synonyms/Alias:Thyroliberin acetate salt;40216-95-3;acetic acid;(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;TRF Acetate;PGLU-HIS-PRO AMIDE ACETATE SALT;SCHEMBL4406163;DTXSID00739560;AKOS030485975;AKOS040759053;TS-09569;Protirelin Acetate(24305-27-9 free base);F85399;Acetic acid--5-oxo-L-prolyl-L-histidyl-L-prolinamide (1/1);(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide acetate;
PGLU-HIS-PRO amide acetate salt, also known as pyroglutamyl-histidyl-proline amide acetate, is a synthetic tripeptide derivative that features a unique sequence and amide modification, enhancing its stability and solubility in aqueous environments. Characterized by its high degree of purity and consistent batch-to-batch performance, this compound is widely valued in biochemical research and peptide-based technology development. Its acetate salt form further improves its handling and integration into a variety of experimental systems, making it a preferred choice for applications requiring precise peptide activity and reliable molecular interactions. The structure of PGLU-HIS-PRO amide supports its use in studies focused on peptide signaling, enzymatic processing, and receptor binding, offering versatility for a broad range of scientific investigations.
Peptide Receptor Interaction Studies: PGLU-HIS-PRO amide acetate salt serves as a valuable model peptide for exploring receptor-ligand dynamics in cell signaling research. By mimicking endogenous peptide sequences, it enables the characterization of binding affinities, receptor selectivity, and downstream signaling pathways in in vitro assays. Researchers often employ this tripeptide to investigate the specificity of G protein-coupled receptors or other peptide-sensitive membrane proteins, facilitating the identification of novel modulators and the elucidation of peptide-mediated communication mechanisms in various biological systems.
Enzymatic Processing and Degradation Assays: In enzymology, the tripeptide is frequently utilized to probe the activity of peptidases and proteases responsible for peptide cleavage and modification. Its defined sequence and amide-capped C-terminus allow for precise monitoring of enzymatic hydrolysis, supporting the discovery of substrate preferences, reaction kinetics, and potential inhibitors. This application is particularly relevant for understanding metabolic pathways involving peptide turnover and for developing enzyme-targeted screening assays in drug discovery research.
Peptide Structure-Activity Relationship (SAR) Analysis: The structural attributes of PGLU-HIS-PRO amide acetate salt make it an excellent tool for SAR studies, wherein researchers systematically modify peptide sequences to assess their impact on biological activity. By substituting or extending the tripeptide's residues, scientists can delineate critical features required for function, optimize binding interactions, and design new analogs with enhanced properties. Such insights are instrumental in the rational development of peptide-based probes, diagnostics, and research reagents.
Neurochemical Research: Due to its resemblance to certain neuropeptide motifs, this compound is often employed in neurochemical studies aimed at understanding peptide signaling in the central nervous system. It can be used to model the interaction of endogenous peptides with neuronal receptors, investigate peptide transport across neural membranes, and study the modulation of neurotransmitter release. These investigations contribute to a deeper understanding of neuropeptide function and regulation in both physiological and pathological contexts.
Peptide-Based Biosensor Development: The stability and specificity of PGLU-HIS-PRO amide acetate salt make it a suitable candidate for incorporation into biosensor platforms designed for peptide detection or quantification. By immobilizing the tripeptide onto sensor surfaces, researchers can create highly selective recognition elements for monitoring enzyme activity, detecting biomolecular interactions, or quantifying target analytes in complex samples. This approach supports the advancement of analytical technologies in fields such as environmental monitoring, food safety, and biomedical research.
Bioconjugation and Peptide Engineering: In the realm of peptide engineering, PGLU-HIS-PRO amide acetate salt is often used as a scaffold for bioconjugation experiments and the synthesis of multifunctional peptide constructs. Its accessible functional groups enable site-specific attachment of labels, affinity tags, or other bioactive moieties, facilitating the creation of tailored reagents for imaging, affinity purification, or targeted delivery studies. By leveraging its modular design, scientists can expand the utility of this tripeptide in diverse research applications, driving innovation in the development of next-generation peptide tools and molecular probes.
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