Pro-Lys is a dipeptide combining a conformationally restricted proline with a basic lysine side chain. Researchers use it to study peptide bending, electrostatic influences, and backbone mobility. The motif supports exploration of β-turn behavior and ligand-binding contributions. Its compact structure facilitates controlled mechanistic analysis.
CAT No: R2315
CAS No:71227-70-8
Synonyms/Alias:Pro-Lys;L-Prolyl-L-lysine;H-Pro-Lys-OH;Prolyl-Lysine;71227-70-8;L-Pro-L-Lys;CHEBI:74792;(2S)-6-amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoic Acid;H-Pro-Lys-OHacetatesalt;CHEMBL377325;PK dipeptide;P-K Dipeptide;H-PRO-LYS-OH ACETATE SALT;Proline Lysine dipeptide;Proline-Lysine dipeptide;(2S)-6-amino-2-(((2S)-pyrrolidine-2-carbonyl)amino)hexanoic acid;6-Amino-2-((hydroxy(pyrrolidin-2-yl)methylidene)amino)hexanoate;6-Amino-2-{[hydroxy(pyrrolidin-2-yl)methylidene]amino}hexanoate;SCHEMBL18075734;HY-P4558;BDBM50188505;FP108159;CS-0655117;Q27144903;
Pro-Lys, also known as L-Lysine or L-Lysine HCl, is a fundamental carbohydrate compound widely recognized for its versatile applications in biochemical research and industrial processes. As an essential amino acid, Pro-Lys plays a pivotal role in protein biosynthesis, providing critical support for various metabolic pathways. Its unique molecular structure, featuring a positively charged side chain, enables specific interactions with other biomolecules, making it a valuable tool in studies involving peptide synthesis, enzyme function, and molecular recognition. Researchers and industry professionals alike utilize Pro-Lys for its solubility, stability, and compatibility with a wide range of experimental conditions, ensuring reliable performance across multiple scientific disciplines.
Peptide Synthesis: Pro-Lys is extensively used as a building block in the solid-phase synthesis of peptides and proteins. Its incorporation into peptide chains allows for the creation of structurally diverse molecules, facilitating the study of protein folding, conformational dynamics, and structure-activity relationships. The presence of the lysine side chain also offers a functional handle for site-specific labeling, conjugation, or modification, which is particularly valuable in the development of peptide-based probes, therapeutics, and biomaterials. By enabling precise control over peptide composition and structure, Pro-Lys supports advancements in protein engineering and functional analysis.
Enzyme Activity Studies: In enzymology, L-Lysine serves as a crucial substrate or cofactor for numerous enzymes, including lysine-specific demethylases, transaminases, and oxidases. Its role in these enzymatic reactions allows researchers to dissect catalytic mechanisms, investigate substrate specificity, and develop novel inhibitors or activators. By providing a consistent and well-characterized substrate, Pro-Lys contributes to the reproducibility and accuracy of enzyme assays, screening campaigns, and mechanistic studies, ultimately driving progress in the understanding of enzymatic regulation and function.
Cell Culture and Metabolic Research: L-Lysine is an indispensable component of cell culture media, supporting the growth and maintenance of a wide range of prokaryotic and eukaryotic cells. Its supplementation ensures the availability of essential nutrients required for cellular proliferation, protein synthesis, and metabolic homeostasis. In metabolic research, Pro-Lys is utilized to trace amino acid utilization, investigate metabolic fluxes, and study the regulation of nitrogen metabolism. Its role in these applications enables researchers to elucidate fundamental biological processes and optimize cell-based production systems for recombinant proteins and other bioproducts.
Protein Modification and Conjugation: The ε-amino group of lysine residues is frequently targeted for chemical modification, bioconjugation, and cross-linking in protein chemistry. Pro-Lys provides a reactive site for the attachment of labels, fluorophores, affinity tags, or therapeutic payloads, expanding the functionality of proteins and peptides. These modifications are instrumental in the development of advanced research tools, diagnostic reagents, and targeted delivery systems. By offering a reliable source of lysine for conjugation strategies, Pro-Lys enhances the versatility and utility of protein-based technologies.
Nutritional Biochemistry and Food Science: In the field of nutritional biochemistry, L-Lysine is investigated for its role in dietary supplementation, food fortification, and animal nutrition. Its essentiality in human and animal diets underscores its importance in studies related to protein quality, amino acid balance, and nutritional requirements. Pro-Lys is also used as a reference compound in analytical assays for amino acid quantification and food composition analysis. By supporting research in nutrition and food science, it contributes to the development of improved dietary formulations and a deeper understanding of amino acid metabolism.
Biomaterials Development: The functional properties of Pro-Lys make it an attractive component in the design of biomaterials, hydrogels, and tissue engineering scaffolds. Its ability to promote cell adhesion, modulate surface charge, and participate in cross-linking reactions enables the creation of materials with tailored biological and physicochemical characteristics. Researchers employ L-Lysine in the fabrication of biocompatible coatings, drug delivery systems, and regenerative medicine constructs, leveraging its versatility to address challenges in biomedical engineering and materials science. Through these diverse applications, Pro-Lys continues to drive innovation and discovery across the life sciences and biotechnology sectors.
2. Emu oil in combination with other active ingredients for treating skin imperfections
5. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.