Psma I&S provides a structured peptide-based system commonly used to investigate targeting motifs and ligand orientation. Its design supports analyses of binding affinity, conformational adaptability, and sequence-derived specificity. Researchers explore its behavior in modeling surface interactions and receptor-recognition patterns. Broader applications span molecular imaging probe design, peptide chemistry, and affinity optimization.
CAT No: R2445
CAS No:2639475-07-1
Synonyms/Alias:PSMA I&S;2639475-07-1;EX-A8579;HY-148152;CS-0613795;(2S)-2-[[(1S)-1-carboxy-5-[[8-[[(5R)-5-carboxy-5-[[(2R)-2-[[(2R)-2-[[(2R)-3-hydroxy-2-[[(2R)-3-hydroxy-2-[[(2R)-3-hydroxy-2-[(2-sulfanylacetyl)amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]pentyl]amino]-8-oxooctanoyl]amino]pentyl]carbamoylamino]pentanedioic acid;
Psma I&S, also known as Prostate-Specific Membrane Antigen Inhibitor & Substrate, is a specialized carbohydrate compound designed for advanced biochemical and molecular research. Characterized by its unique structural features, Psma I&S offers significant value in the investigation of cell-surface antigen interactions, especially in the context of prostate-related studies. Its molecular configuration allows for high-affinity binding and selective targeting, making it an indispensable tool for researchers aiming to dissect complex biological pathways. The compound's compatibility with a variety of assay systems further enhances its versatility, supporting both in vitro and in vivo experimental designs across multiple scientific disciplines.
Target Validation in Oncology Research: In cancer biology, Psma I&S serves as a critical agent for the validation of PSMA as a biomarker in prostate cancer models. Researchers employ this compound to map the expression patterns of PSMA on tumor cells, facilitating the identification of malignant versus benign tissues. Through selective binding, it assists in elucidating the role of PSMA in tumor progression and metastasis, enabling a deeper understanding of the molecular mechanisms driving cancer development. This application is instrumental in the discovery of new therapeutic targets and in the assessment of disease prognosis.
Molecular Imaging Probe Development: The unique affinity properties of Psma I&S make it a valuable starting point for the design and optimization of molecular imaging probes. Scientists utilize it to develop and refine agents for non-invasive imaging modalities, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). By serving as a molecular scaffold, it supports the creation of highly specific probes that can visualize PSMA-expressing tissues in real time. This capability significantly advances preclinical imaging studies and the evaluation of disease models.
Enzyme Kinetics and Inhibitor Screening: As a substrate analog, Psma I&S is widely used in enzymology to investigate the catalytic activity of PSMA and related enzymes. Its structural mimicry allows for detailed kinetic analyses, enabling researchers to measure enzyme-substrate interactions, determine catalytic rates, and evaluate the efficacy of novel inhibitors. This application is essential for drug discovery programs focused on developing selective PSMA inhibitors, as it provides a reliable platform for high-throughput screening and mechanistic studies.
Antibody and Ligand Development: The compound's well-defined epitope presentation makes it an ideal tool for the generation and screening of monoclonal antibodies and synthetic ligands targeting PSMA. Researchers exploit its specificity to select and characterize high-affinity binding molecules, which can be further developed for diagnostic or research applications. By providing a consistent and reproducible antigenic target, it accelerates the development of novel affinity reagents and supports the advancement of immunological assays.
Cellular Uptake and Trafficking Studies: Psma I&S also plays a pivotal role in studying the internalization and intracellular trafficking of PSMA and its ligands. Through labeling and tracking experiments, scientists can monitor the endocytosis of PSMA complexes, investigate cellular routing pathways, and assess the impact of various modifiers on antigen processing. These insights contribute to a more comprehensive understanding of PSMA biology and inform the rational design of targeted delivery systems for research purposes.
Bioconjugation and Nanotechnology Research: In the realm of bioconjugation, Psma I&S provides a reliable functional group for coupling with a range of biomolecules, nanoparticles, and imaging agents. Researchers leverage its chemical properties to engineer multifunctional constructs that combine targeting, imaging, and therapeutic functionalities. This approach is particularly valuable in the development of next-generation nanomaterials and biosensors, where precise targeting and modular design are critical for performance. By integrating it into complex assemblies, scientists are able to push the boundaries of molecular diagnostics and targeted research tools.
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