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R 715

Potent and selective antagonist of bradykinin b1 receptor (pa2 = 8.49), which displays no activity at b2 receptors, and reduces mechanical hypernociception in a mouse model of neuropathic pain.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
R 715(CAS 185052-09-9)

CAT No: R1087

CAS No:185052-09-9

Synonyms/Alias:185052-09-9;R 715;R715;(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-methylpentanoic acid;R-715;CHEMBL410363;AKOS024457611;DA-77310;HY-103290;CS-0027164;AcLys(D-betaNal(7),Ile(8))des-Arg(9)-bradykinin;

Custom Peptide Synthesis
cGMP Peptide
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  • CMC information required for an IND
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M.F/Formula
C57H81N13O12
M.W/Mr.
1140.3
Sequence
One Letter Code:KRPPGFSXI
Three Letter Code:Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D-2Nal-Ile-OH
Labeling Target
Bradykinin Receptors
Appearance
White lyophilised solid
Purity
>98%
Activity
Antagonist
Long-term Storage Conditions
Soluble in water
InChI
InChI=1S/C57H81N13O12/c1-4-34(2)48(56(81)82)68-51(76)43(31-37-23-24-38-17-8-9-18-39(38)29-37)66-52(77)44(33-71)67-50(75)42(30-36-15-6-5-7-16-36)64-47(73)32-62-53(78)45-21-13-27-69(45)55(80)46-22-14-28-70(46)54(79)41(20-12-26-61-57(59)60)65-49(74)40(63-35(3)72)19-10-11-25-58/h5-9,15-18,23-24,29,34,40-46,48,71H,4,10-14,19-22,25-28,30-33,58H2,1-3H3,(H,62,78)(H,63,72)(H,64,73)(H,65,74)(H,66,77)(H,67,75)(H,68,76)(H,81,82)(H4,59,60,61)/t34-,40-,41-,42-,43+,44-,45-,46-,48-/m0/s1
InChI Key
DOSXOGUJJBDRGQ-VUBDHFCFSA-N
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@@H]4CCCN4C(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)C
BoilingPoint
N/A
Melting Point
N/A

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