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Rapamycin

Rapamycin is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: Z10-101-156

CAS No:53123-88-9

Synonyms/Alias:Sirolimus; Rapamune; 53123-88-9; AY 22 989; I 2190A

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  • Drug master files (DMF) filing
M.F/Formula
C51H79NO13
M.W/Mr.
914.18
Labeling Target
Serine/threonine-protein kinase mTOR
Application
Rapamycin is a potent immunosuppressant, and have both antifungal and antineoplastic properties.
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Activity
Inhibitor
Biological Activity
Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases.
Areas of Interest
Immunosuppressant; Lymphangioleiomyomatosis (LAM)
Functions
Tfiiic-class transcription factor binding
Target
mTOR
Long-term Storage Conditions
Soluble in DMSO, not in water
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
Organism
Human
InChI
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI Key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
BoilingPoint
973.0±75.0 °C at 760 mmHg
ShelfLife
>2 years if stored properly
Melting Point
183-185°C

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