Receptor tyrosine-protein kinase erbB-2
CAT No: ta-341
Synonyms/Alias:Receptor tyrosine-protein kinase erbB-2 (402-410)
Receptor tyrosine-protein kinase erbB-2 (402-410) is a synthetic peptide fragment corresponding to amino acid residues 402 to 410 of the human erbB-2/HER2 protein sequence. As a well-defined segment of the erbB-2 receptor, this peptide is highly relevant in the study of receptor tyrosine kinases, a family of cell surface proteins that play essential roles in signal transduction pathways governing cell growth, differentiation, and survival. The erbB-2 protein, also known as HER2, is a prominent member of the epidermal growth factor receptor (EGFR) family and is widely studied for its involvement in cellular signaling cascades and its overexpression in various malignancies. The defined sequence of this peptide enables precise investigations into the structure-function relationships, binding interactions, and immunological properties of the erbB-2 receptor, making it a valuable tool in biochemical and molecular research contexts.
Epitope mapping: Synthetic peptides derived from receptor tyrosine kinases, such as the erbB-2 (402-410) fragment, are instrumental in mapping antigenic determinants within the parent protein. By providing a specific linear sequence, this peptide allows researchers to identify regions recognized by antibodies or other binding partners. Such mapping is crucial for understanding immune recognition and for the development of targeted research reagents, including monoclonal antibodies and diagnostic probes that selectively interact with the erbB-2 receptor.
Signal transduction studies: The erbB-2 (402-410) peptide serves as a model substrate for dissecting the molecular mechanisms underlying receptor-mediated signaling. It can be employed in kinase assays and protein interaction studies to probe phosphorylation events, binding affinities, or conformational changes associated with the activation of the HER2/erbB-2 receptor. These insights are fundamental to elucidating the role of specific sequence motifs in downstream signaling pathways and cellular responses.
Peptide-based assay development: Defined peptide fragments such as this one are frequently incorporated into in vitro assays designed to monitor protein-protein interactions, enzyme activities, or antibody specificity. The erbB-2 (402-410) peptide provides a reliable and reproducible standard for establishing ELISA, Western blot, or immunoprecipitation protocols, facilitating the quantitative analysis of binding events or enzymatic modifications related to the erbB-2 receptor.
Immunological research: As a representative epitope from the HER2 protein, this peptide is utilized in studies aimed at characterizing T-cell or B-cell responses to erbB-2-derived antigens. It enables the evaluation of immune recognition, cross-reactivity, and the generation of peptide-specific immune reagents. Such research supports the broader investigation of immune surveillance mechanisms, tolerance, and the development of peptide-based immunological tools for basic and translational research.
Structural and conformational analysis: The erbB-2 (402-410) peptide is suitable for structural biology applications, including NMR spectroscopy and computational modeling. Its defined sequence allows for the exploration of local secondary structure, solvent accessibility, and interaction surfaces, providing valuable information on the conformational preferences of the erbB-2 receptor's extracellular domain. These structural insights contribute to a deeper understanding of how sequence motifs influence receptor function and intermolecular recognition.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More