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Salcaprozate sodium

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Salcaprozate sodium(CAS 203787-91-1)

CAT No: R1937

CAS No:203787-91-1

Synonyms/Alias:Salcaprozate sodium;203787-91-1;sodium 8-(2-hydroxybenzamido)octanoate;SNAC;Salcaprozate sodium [USAN];sodium 8-[(2-hydroxybenzoyl)amino]octanoate;Sodium salcaprozate;sodium;8-[(2-hydroxybenzoyl)amino]octanoate;E414;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt;UNII-1YTW0422YU;Salcaprozic acid, sodium salt;1YTW0422YU;Salcaprozate (sodium);MFCD00952954;Salcaprozate sodium (USAN);E 414;E-414;Sodium 8-((2-hydroxybenzoyl)amino)octanoate;DTXSID50174306;sodium,8-[(2-hydroxybenzoyl)amino]octanoate;Octanoic acid, 8-((2-hydroxybenzoyl)amino)-, monosodium salt;Salcaprozic acid sodium salt;P414;C15H20NNaO4;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt;SNAC sodium;SCHEMBL825599;CHEMBL2107027;DTXCID3096797;Salcaprozate (sodium) (Standard);UOENJXXSKABLJL-UHFFFAOYSA-M;EX-A3434;Sodium 8-(salicyloylamino)octanoate;sodium8-(2-hydroxybenzamido)octanoate;AKOS027252576;HY-114299R;AC-31357;AS-65676;DA-67382;FS168567;SY111977;HY-114299;CS-0081977;D05787;I10998;Q27253228;SODIUM 8-[(2-HYDROXYPHENYL)FORMAMIDO]OCTANOATE;807-387-2;

Chemical Name:sodium;8-[(2-hydroxybenzoyl)amino]octanoate

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cGMP Peptide
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M.F/Formula
C15H20NNaO4
M.W/Mr.
301.31
Application
Delivery agent
Long-term Storage Conditions
10 mM in DMSO
InChI
InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1
InChI Key
UOENJXXSKABLJL-UHFFFAOYSA-M
Canonical SMILES
C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+]
References
1. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93.
2. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78.
3. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990.

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