Saralasin ([Sar1], [Ala8]-Ang II) is a partial agonist of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist.
CAT No: 10-101-304
CAS No:34273-10-4
Synonyms/Alias:Saralasin;34273-10-4;Saralasina;Saralasine;Saralasinum;Sar-Arg-Val-Tyr-Val-His-Pro-Ala;Saralasinum [INN-Latin];Saralasin [INN:BAN];Saralasine [INN-French];Saralasina [INN-Spanish];DTXSID2046549;(Sar1,Val5,Ala8)-Angiotensin II;CHEMBL938;H2AFV2HE66;1-Sar-8-Ala-angiotensin II;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;DTXCID0026549;Angiotensin II, 1-(N-methylglycine)-5-L-valine-8-L-alanine-;(Sar(1),Ala(8))ANGII;(1-(N-Methylglycin) 5-L-valin, 8-L-alanin)angiotensin II;Saralasine (INN-French);Saralasinum (INN-Latin);Saralasina (INN-Spanish);N-(1-(N-(N-(N-(N-(N2-(N-methylglycly)-L-arginyl)-L-valyl)-L-tyrosyl)-L-valyl)-L-histidyl)-L-prolyl)-L-alanine;UNII-H2AFV2HE66;1 Sar 8 Ala Angiotensin II;1-Sar-8-Ala Angiotensin II;Angiotensin II, 1-Sar-8-Ala;(Sar1,Val5,Ala8)Angiotensin II;NCGC00166135-01;(2S)-2-(((2S)-1-((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-5-(diaminomethylideneamino)-2-((2-(methylamino)acetyl)amino)pentanoyl)amino)-3-methylbutanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)-3-methylbutanoyl)amino)-3-(1H-imidazol-5-yl)propanoyl)pyrrolidine-2-carbonyl)amino)propanoic acid;angiotensin II, Sar(1)-Ala(8)-;1 Sarcosine 8 Alanine Angiotensin II;1-Sarcosine-8-Alanine Angiotensin II;Angiotensin II, 1-Sarcosine-8-Alanine;angiotensin II, sarcosyl(1)-alanine(8)-;SARALASIN [INN];SARALASIN [MI];SCHEMBL23;CHEBI:135894;2-((1-(2-((2-((2-((2-((5-(diaminomethylideneamino)-2-((2-methylaminoacetyl)amino)pentanoyl)amino)-3-methylbutanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)-3-methylbutanoyl)amino)-3-(3H-imidazol-4-yl)propanoyl)pyrrolidine-2-carbonyl)amino)propanoic acid;2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[(2-methylaminoacetyl)amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;HY-P0205;Tox21_112332;BDBM50009338;BDBM50229504;AKOS024456428;DB06763;NCGC00167316-01;FS108389;CAS-34273-10-4;CS-0021297;NS00073478;Sar-Arg-Val-Tyr-Val-His-Pro-Ala (sarlasin);[Sar1-Arg2-Val3-Tyr4-Val5-His6-Pro7-Ala8];Q410298;(Sar 1,Val5,Ala8)-Angiotensin II trifluoroacetate salt;ANGIOTENSIN II, 1-SARCOSINE-5-L-VALINE-8-L-ALANINE-;Saralasin;Sar-Arg-Val-Tyr-Val-His-Pro-Ala-OH trifluoroacetate salt;L-ALANINE, N-METHYLGLYCYL-L-ARGINYL-L-VALYL-L-TYROSYL-L-VALYL-L-HISTIDYL-L-PROLYL-;(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-4-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid;(S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(diaminomethyleneamino)-2-(2-(methylamino)acetamido)pentanamido)-3-methylbutanamido)-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)-3-(1H-imidazol-5-yl)propanoyl)pyrrolidine-5-carboxamido)propanoic acid;60173-70-8;
Saralasin, a synthetic peptide analog of angiotensin II, is widely recognized for its unique ability to interact with angiotensin receptors, making it a valuable tool in scientific research. Unlike its natural counterpart, Saralasin incorporates specific amino acid substitutions that confer partial agonist and antagonist properties, allowing researchers to explore the complexities of the renin-angiotensin system with enhanced specificity. Its stability in biological systems and resistance to enzymatic degradation further support its utility in experimental protocols that require prolonged or controlled exposure. As a result, Saralasin has become a preferred reagent in studies investigating physiological and biochemical pathways related to cardiovascular and renal function, as well as in pharmacological profiling of receptor subtypes.
Pharmacological Research: In pharmacological research, Saralasin serves as a key molecule for dissecting the functional roles of angiotensin II receptors, particularly AT1 and AT2 subtypes. By acting as a competitive antagonist and partial agonist, it enables scientists to differentiate between receptor-mediated responses, facilitating a deeper understanding of receptor pharmacodynamics and ligand-receptor interactions. Researchers often employ Saralasin in in vitro and in vivo models to elucidate the contribution of angiotensin II signaling to blood pressure regulation, vascular tone, and electrolyte balance. Its use in receptor binding assays and functional studies provides critical insights into the mechanisms underlying hypertension and other cardiovascular pathologies.
Receptor Characterization: The peptide's unique binding profile makes it an ideal probe for characterizing angiotensin receptor populations in various tissues. By selectively blocking or activating specific receptor subtypes, Saralasin allows for precise mapping of angiotensin II receptor distribution and density. This information is essential for understanding tissue-specific responses to angiotensin II and for identifying novel therapeutic targets. Studies utilizing Saralasin have contributed to the identification of receptor heterogeneity within the cardiovascular and renal systems, advancing the field of receptor biology and informing drug development strategies.
Signal Transduction Studies: Saralasin is also instrumental in signal transduction research, where it is used to delineate the downstream effects of angiotensin receptor activation or inhibition. By modulating receptor activity, the compound aids in unraveling complex intracellular signaling pathways, such as those involving calcium flux, protein kinase activation, and gene expression changes. These investigations are crucial for identifying the molecular events that drive physiological and pathological processes, including vascular remodeling, inflammation, and cellular proliferation. The ability to manipulate signaling cascades with Saralasin enhances the precision of experimental designs and supports the discovery of new molecular targets.
Renal Physiology Exploration: In the field of renal physiology, Saralasin is frequently employed to investigate the role of the renin-angiotensin system in kidney function and fluid homeostasis. Its application in isolated organ perfusion studies, cell culture experiments, and animal models enables detailed examination of angiotensin-mediated effects on glomerular filtration, sodium reabsorption, and renal hemodynamics. Researchers utilize Saralasin to distinguish between direct and indirect actions of angiotensin II on renal cells, providing valuable data for understanding the regulation of blood volume and electrolyte balance.
Vascular Function Assessment: Studies focused on vascular function benefit from the use of Saralasin to probe the mechanisms of vasoconstriction and vasodilation. By selectively modulating angiotensin receptor activity, the peptide facilitates the assessment of endothelial and smooth muscle responses to hormonal stimuli. This approach is instrumental in identifying alterations in vascular reactivity associated with disease states and in evaluating the efficacy of novel pharmacological agents targeting the renin-angiotensin system. The insights gained from such investigations contribute to the broader understanding of cardiovascular regulation and the development of innovative therapeutic interventions.
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