Selank is a 7-amino-acid peptide that is the synthetic equivalent of the naturally occurring peptide called tuftsin.
CAT No: HB00113
CAS No:129954-34-3
Synonyms/Alias:Selank;129954-34-3;Selanc;Thr-Lys-Pro-Arg-Pro-Gly-Pro;TP-7;L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-;TP 7;UNII-TS9JR8EP1G;TS9JR8EP1G;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline;Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline;(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid;Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline [WHO-DD];DTXSID701029276;GLXC-15287;AKOS040744609;DA-77782;HY-105042;CS-0024768;L-Proline, 1-(N-(1-(N2-(1-(N2-L-threonyl-L-lysyl)-L-prolyl)-L-arginyl)-L-prolyl)glycyl)-;
Selank is a synthetic peptide belonging to the class of heptapeptides, structurally derived from the naturally occurring immunomodulatory peptide tuftsin. Recognized for its unique sequence and stability, Selank has garnered significant interest in biochemical and neurobiological research due to its multifaceted functional properties. Its molecular architecture allows it to interact with key regulatory systems, making it a valuable tool for investigating neuropeptide signaling, cognitive modulation, and immune system mechanisms. As a research-use compound, Selank provides a robust platform for exploring peptide-based modulation of central nervous system activity and immune responses in a controlled laboratory setting.
Neuroscience research: Selank is widely utilized in neurobiology to elucidate the roles of synthetic peptides in modulating neurotransmitter systems, particularly those associated with anxiety, cognition, and emotional regulation. Its ability to influence the expression and activity of monoamine neurotransmitters, such as serotonin and dopamine, renders it a powerful probe for studying the molecular underpinnings of neuropsychiatric and cognitive processes. Researchers employ Selank in vitro and in vivo models to map peptide-mediated signaling pathways and to dissect the peptide's effects on synaptic plasticity, neurogenesis, and neural network dynamics.
Immunological studies: The structural similarity of Selank to tuftsin underpins its use in immunological research, where it serves as a model for investigating peptide-mediated modulation of immune cell activity. Experimental work has demonstrated that Selank can impact cytokine production, macrophage function, and other aspects of innate and adaptive immunity. By enabling the controlled study of peptide-immune system interactions, Selank supports the development of novel insights into immunoregulation, host defense mechanisms, and the biochemical crosstalk between the nervous and immune systems.
Peptide receptor characterization: As a synthetic peptide with defined bioactivity, Selank is instrumental in the identification and characterization of neuropeptide receptors and binding sites. Researchers employ it to probe receptor specificity, binding affinities, and downstream signaling cascades in neuronal and immune cell populations. Such studies contribute to a deeper understanding of peptide-receptor interactions, facilitate the discovery of novel receptor subtypes, and inform the rational design of new peptide analogs with targeted functional profiles.
Peptide synthesis and analytical validation: Selank also serves as a reference standard and quality control benchmark in peptide synthesis laboratories. Its well-characterized structure and physicochemical properties make it suitable for validating synthetic protocols, optimizing purification strategies, and calibrating analytical techniques such as HPLC and mass spectrometry. By providing a reliable model peptide, Selank supports advancements in synthetic methodology and ensures reproducibility in peptide production workflows.
Behavioral pharmacology: In preclinical research, Selank is employed to investigate the behavioral effects of neuroactive peptides in animal models. Its administration allows scientists to assess changes in learning, memory, stress response, and social behaviors, thereby offering a window into the complex interplay between peptide signaling and behavioral phenotypes. These studies help delineate the functional consequences of peptide modulation in the central nervous system and support the broader field of behavioral neuroscience.
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