Selank is a 7-amino-acid peptide that is the synthetic equivalent of the naturally occurring peptide called tuftsin.
CAT No: HB00113
CAS No:129954-34-3
Synonyms/Alias:Selank;129954-34-3;Selanc;Thr-Lys-Pro-Arg-Pro-Gly-Pro;TP-7;L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-;TP 7;UNII-TS9JR8EP1G;TS9JR8EP1G;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline;Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline;(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid;Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline [WHO-DD];DTXSID701029276;GLXC-15287;AKOS040744609;DA-77782;HY-105042;CS-0024768;L-Proline, 1-(N-(1-(N2-(1-(N2-L-threonyl-L-lysyl)-L-prolyl)-L-arginyl)-L-prolyl)glycyl)-;
Selank, also known as Selanc or Thr-Lys-Pro-Arg-Pro-Gly-Pro, is a synthetic peptide with a structure derived from the naturally occurring human tetrapeptide tuftsin. Characterized by its unique molecular composition, Selank exhibits high stability and solubility, making it suitable for a range of research applications in neuroscience and biochemistry. Its ability to cross the blood-brain barrier and interact with various neurochemical pathways has garnered significant attention in scientific circles. Researchers value Selank for its multifaceted biological activities, which include modulating neurotransmitter systems and influencing gene expression associated with cognitive function. As a result, it has become an important tool for investigating the molecular mechanisms underlying brain physiology and behavior.
Neurotransmitter Regulation: In the study of neurotransmitter regulation, Selank plays a pivotal role due to its capacity to influence the balance of key neurotransmitters such as serotonin, dopamine, and norepinephrine. By modulating the activity of these neurotransmitter systems, it enables researchers to explore the intricate processes governing mood, cognition, and stress response. Studies have demonstrated that Selank can alter the expression and activity of enzymes involved in neurotransmitter synthesis and degradation, providing valuable insights into the treatment of neuropsychiatric disorders and the development of novel therapeutic strategies targeting neurotransmitter imbalances.
Cognitive Function Research: Thr-Lys-Pro-Arg-Pro-Gly-Pro is widely utilized in cognitive function research, where its effects on memory, learning, and attention are of particular interest. Scientists employ this peptide in experimental models to dissect the molecular pathways that underlie cognitive processes. Its interaction with brain-derived neurotrophic factor (BDNF) and other neurotrophic factors has been shown to support synaptic plasticity and neuronal survival, which are critical for optimal cognitive performance. These properties make Selank a valuable asset in the quest to understand the biochemical basis of learning and memory formation.
Anxiolytic Mechanisms: The investigation of anxiolytic mechanisms benefits significantly from the use of Selanc. Researchers have observed that it can modulate the expression of genes associated with anxiety and stress responses, as well as influence the activity of the GABAergic system, which plays a crucial role in the regulation of anxiety. By providing a non-benzodiazepine approach to anxiety modulation, Selank enables the study of alternative pathways for managing stress and anxiety-like behaviors, broadening the scope of neuropsychiatric research.
Immunomodulation Studies: Selank's origin as a derivative of tuftsin—a known immunomodulatory peptide—positions it as a valuable tool in immunological research. Experimental evidence suggests that it can affect cytokine production and modulate the activity of immune cells such as macrophages. These effects are of particular interest in studies exploring the neuroimmune interface and the ways in which immune modulation can impact central nervous system function. Through its dual action on neural and immune pathways, Selank supports a deeper understanding of the bidirectional communication between the brain and immune system.
Epigenetic and Gene Expression Research: In the realm of epigenetic and gene expression research, Selank is employed to investigate how neuropeptides can influence the transcriptional landscape of neuronal cells. Its ability to modulate the expression of genes involved in neurotransmission, neuroprotection, and synaptic plasticity provides a platform for studying the molecular underpinnings of brain adaptability. By examining the epigenetic modifications induced by Selank, researchers can gain new perspectives on the regulation of gene networks that govern brain development and function, ultimately contributing to the advancement of neurobiology and molecular genetics.
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