Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.
CAT No: HB00098
CAS No: 920014-72-8
Synonyms/Alias: Setmelanotide;920014-72-8;RM-493;BIM-22493;Setmelanotida;Setmelanotide acetate;UNII-N7T15V1FUY;N7T15V1FUY;(4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide;1504602-49-6;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2->8)-disulfide;Setmelanotide [USAN:INN];Setmelanotidum;Setmelanotide [USAN];Setmelanotide (RM-493);SETMELANOTIDE [INN];SETMELANOTIDE [WHO-DD];GTPL9272;CHEMBL3301624;SCHEMBL21840385;DTXSID501032320;EX-A5542;BDBM50581319;AT23144;CS-6399;DB11700;IRC-022493;DA-67236;DA-77812;HY-19870;Q21098917;RM-493; BIM-22493; IRC-022493;N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2-8)-disulfide;
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M.F/Formula | C49H68N18O9S2 |
M.W/Mr. | 1117.3 |
Sequence | One Letter Code:RCAHFRWC Three Letter Code:Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2 |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
InChI | InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1 |
InChI Key | HDHDTKMUACZDAA-PHNIDTBTSA-N |
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