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Setmelanotide

Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Setmelanotide(CAS 920014-72-8)

CAT No: HB00098

CAS No:920014-72-8

Synonyms/Alias:Setmelanotide;920014-72-8;RM-493;BIM-22493;Setmelanotida;Setmelanotide acetate;UNII-N7T15V1FUY;N7T15V1FUY;(4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide;1504602-49-6;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2->8)-disulfide;Setmelanotide [USAN:INN];Setmelanotidum;Setmelanotide [USAN];Setmelanotide (RM-493);SETMELANOTIDE [INN];SETMELANOTIDE [WHO-DD];GTPL9272;CHEMBL3301624;SCHEMBL21840385;DTXSID501032320;EX-A5542;BDBM50581319;AT23144;CS-6399;DB11700;IRC-022493;DA-67236;DA-77812;HY-19870;Q21098917;RM-493; BIM-22493; IRC-022493;N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2-8)-disulfide;

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M.F/Formula
C49H68N18O9S2
M.W/Mr.
1117.3
Sequence
One Letter Code:RCAHFRWC
Three Letter Code:Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1
InChI Key
HDHDTKMUACZDAA-PHNIDTBTSA-N

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