Sulfo-GMBS is a water-soluble, sulfonated heterobifunctional crosslinker derived from a maleimide-N-hydroxysuccinimide (NHS) framework, designed for coupling to thiol and primary amine functional groups in aqueous media. The molecule contains a maleimide moiety that reacts with nucleophilic thiols to form a stable thioether linkage and an NHS-activated ester that can acylate primary amines, while the sulfonate substituent increases hydrophilicity and supports handling in buffered solutions. In biochemical workflows, Sulfo-GMBS is used to generate defined protein-protein or protein-surface conjugates and to prepare crosslinked peptide or biomolecular constructs for structural studies, chemical biology labeling, and analytical method development.
CAT No: CP26564
CAS No:185332-92-7
Synonyms/Alias:Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt;Sulfo-GMBS
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