TFFYGGSRGKRNNFKTEEYC is a charged, aromatic-rich peptide with mixed secondary-structure tendencies. The sequence aids examination of protein-protein recognition, electrostatic interactions, and structural plasticity. Researchers apply it to mapping folding motifs and solvent-dependent conformational changes. Its length supports in-depth biophysical analysis.
CAT No: R1933
CAS No:906480-09-9
Synonyms/Alias:TFFYGGSRGKRNNFKTEEYC;906480-09-9;L-Cysteine, L-threonyl-L-phenylalanyl-L-phenylalanyl-L-tyrosylglycylglycyl-L-seryl-L-arginylglycyl-L-lysyl-L-arginyl-L-asparaginyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-threonyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-;
Chemical Name:4-[[2-[[2-[[6-amino-2-[[2-[[4-amino-2-[[4-amino-2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-amino-3-hydroxybutanoyl)amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-5-[[1-[(1-carboxy-2-sulfanylethyl)amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
TFFYGGSRGKRNNFKTEEYC is a synthetic peptide composed of a defined sequence of amino acids, designed to support advanced research in peptide biochemistry and molecular biology. As a linear peptide, it features a unique arrangement of residues that can mimic, modulate, or probe specific biological interactions, making it a valuable tool in both fundamental and applied peptide science. Its defined sequence and customizable nature allow researchers to explore structure-function relationships, receptor binding dynamics, and signal transduction pathways. The availability of such a peptide enables precise experimental design, facilitating the study of molecular mechanisms that underlie complex biological systems.
Peptide structure-function analysis: In the context of structural biology and protein engineering, this peptide serves as a model substrate for elucidating the relationship between primary sequence and biological activity. Researchers can use it to systematically investigate how specific amino acid motifs contribute to folding, stability, or functional domains within proteins. By applying techniques such as circular dichroism, NMR spectroscopy, or computational modeling, scientists gain insights into secondary structure formation and the determinants of peptide conformation.
Receptor binding studies: The sequence of TFFYGGSRGKRNNFKTEEYC can be utilized to examine peptide-receptor interactions, particularly in systems where short peptides act as ligands or signaling molecules. Through binding assays, surface plasmon resonance, or fluorescence-based techniques, researchers can quantify affinity, specificity, and kinetics of interaction between the peptide and its target protein. Such studies are essential for mapping binding sites, understanding molecular recognition, and developing peptide-based modulators or inhibitors.
Protease substrate characterization: As a well-defined peptide, it is highly suitable for use as a substrate in enzymatic assays aimed at profiling protease activity and specificity. By monitoring cleavage patterns and reaction kinetics with mass spectrometry or HPLC, investigators can identify protease recognition sequences, determine substrate preferences, and evaluate the effects of sequence modifications. This application is particularly relevant in the study of proteolytic pathways, enzyme inhibitor screening, and the design of protease-resistant analogs.
Peptide synthesis and analytical method development: The defined nature of this peptide makes it an ideal standard or reference material in the optimization and validation of peptide synthesis protocols. It can be used to assess the efficiency of solid-phase peptide synthesis, test purification strategies, and calibrate analytical instrumentation such as LC-MS or HPLC systems. By benchmarking synthetic and analytical workflows, laboratories can ensure reproducibility, accuracy, and quality control in peptide production and characterization.
Cell signaling pathway investigation: In cellular and molecular biology research, synthetic peptides like TFFYGGSRGKRNNFKTEEYC are frequently employed to probe intracellular signaling cascades or modulate protein-protein interactions. By introducing the peptide into cultured cells or in vitro systems, scientists can monitor downstream effects on gene expression, phosphorylation events, or cellular phenotypes. These studies contribute to a deeper understanding of signaling networks, target validation, and the mechanistic basis of cellular responses to peptide stimuli.
2. Myotropic activity of allatostatins in tenebrionid beetles
4. The spatiotemporal control of signalling and trafficking of the GLP-1R
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