Threo-L-β-Hydroxynorleucine is a threonine-like, non-proteinogenic amino acid derivative featuring a straight-chain norleucine backbone bearing a β-hydroxyl substituent and a threo stereochemical relationship with the side-chain hydroxyl. The molecule contains an amino functional group and a carboxyl functional group, with the β-hydroxyl side-chain providing hydrogen-bonding and polarity that can influence peptide conformations and intermolecular interactions, while the L designation specifies the stereochemical form at the amino acid center. As a β-hydroxy amino acid, it is used in peptide synthesis and chemical biology studies to introduce hydroxyl-bearing residues for structure-activity investigations, crosslinking or conjugation strategies requiring a hydroxyl handle, and analytical method development involving defined β-hydroxy amino acid standards.
CAT No: CP07203
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