Thymotrinan is a short regulatory peptide enriched with charged residues that facilitate dynamic secondary-structure transitions. The motif supports analysis of interaction hotspots, conformational plasticity, and hydrogen-bonding networks. Researchers apply it to map protein-binding determinants and structural rearrangements. Its simplicity aids biophysical characterization.
CAT No: R2235
CAS No:85465-82-3
Synonyms/Alias:Thymotrinan;Arg-Lys-Asp;85465-82-3;Thymotrinan [INN];Timotrinan;arginyl-lysyl-aspartic acid;L-Arginyl-L-lysyl-L-aspartic acid;(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]butanedioic acid;THYMOPOIETIN II (32-34);29OE04A6C9;Rgh 0205;Thymotrinanum;RGH-0205;Timotrinan [INN-Spanish];Thymotrinanum [INN-Latin];UNII-29OE04A6C9;RGH 0205; TP 3;N-(N(sup 2)-L-Arginyl-L-lysyl)-L-aspartic acid;SCHEMBL62515;L-Aspartic acid, N-(N(sup 2)-L-arginyl-L-lysyl)-;CHEMBL2105488;SCHEMBL15532089;DTXSID60234687;CHEBI:159125;AKOS040754202;HY-106765;CS-0026503;NS00123466;Q27254434;(S)-2-((S)-6-amino-2-((S)-2-amino-5-guanidinopentanamido)hexanamido)succinic acid;
Thymotrinan is a synthetic peptide compound designed to mimic the functional motifs of endogenous thymic peptides, playing a significant role in immunological and biochemical research. As a member of the peptide class, it is characterized by a specific sequence that confers bioactivity relevant to cellular signaling pathways and immune system modulation. Its structural features make it an important tool for probing the molecular mechanisms underlying thymic hormone activity, as well as for exploring the regulatory networks involved in immune cell differentiation and maturation. Due to its stability and reproducibility, Thymotrinan has become a valuable resource for laboratories focused on peptide-based investigations and the development of novel immunomodulatory strategies.
Peptide signaling pathway analysis: Thymotrinan is frequently utilized in studies aiming to dissect the intricacies of thymic peptide-mediated signaling. By serving as a functional analog of natural thymic hormones, it enables researchers to examine receptor-ligand interactions, downstream signal transduction events, and the modulation of gene expression profiles in immune cells. These investigations provide critical insights into the roles of thymic peptides in immune homeostasis, facilitating the identification of novel regulatory checkpoints within lymphocyte development and function.
Immunological research: In the context of immunology, Thymotrinan is employed to investigate the maturation, differentiation, and activation of T lymphocytes. Its application allows for the controlled stimulation or inhibition of thymic pathways in vitro, supporting the study of cellular responses to peptide-based cues. Such research is instrumental in elucidating the mechanisms by which the thymus orchestrates immune competence and tolerance, contributing to a deeper understanding of immune system disorders and the potential for peptide-driven modulation.
Peptide synthesis and optimization: Thymotrinan serves as a reference standard and model system in the field of synthetic peptide chemistry. Its well-defined sequence and bioactivity make it an ideal candidate for benchmarking new synthetic methodologies, optimizing solid-phase peptide synthesis protocols, and evaluating the impact of sequence modifications on biological function. These activities are essential for advancing peptide engineering, improving yield and purity, and expanding the repertoire of functionally relevant synthetic peptides.
Functional assays and screening: The compound is widely used in the development and validation of functional assays designed to measure peptide-induced biological activity. By incorporating Thymotrinan into cell-based or biochemical assay platforms, researchers can quantify receptor activation, cytokine production, or cellular proliferation in response to defined peptide stimuli. This approach supports high-throughput screening of peptide analogs and provides a robust framework for comparative analyses of structure-activity relationships.
Biochemical tool for mechanistic studies: Owing to its structural and functional resemblance to natural thymic peptides, Thymotrinan is a valuable biochemical tool for mechanistic studies that probe the interplay between peptide ligands and their cognate receptors. Its use facilitates the dissection of molecular interactions, conformational dynamics, and the influence of post-translational modifications on peptide activity. These mechanistic insights are fundamental to the rational design of next-generation immunomodulatory peptides and the advancement of peptide-based research technologies.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
5. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
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