Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules.
CAT No: R1728
CAS No:918629-48-8
Synonyms/Alias:Transdermal Peptide;888486-23-5;2-[[(3S,6S,9R,12R,17R,20S,23S,26S,29S)-23-(4-Aminobutyl)-12-[[(2S)-2-aminopropanoyl]amino]-3,6,9,26-tetrakis(hydroxymethyl)-20-(1H-imidazol-5-ylmethyl)-2,5,8,11,19,22,25,28-octaoxo-27,28lambda4-dithia-1,4,7,10,18,21,24-heptazabicyclo[27.3.0]dotriacontane-17-carbonyl]amino]acetic acid;
Transdermal Peptide is a synthetic peptide compound engineered to facilitate or study the transport of molecules across the skin barrier. As a member of the peptide family, it exhibits unique physicochemical properties that enable it to interact with biological membranes, making it an important tool for research into percutaneous absorption and peptide-mediated delivery systems. Its sequence and structural attributes are designed to optimize skin permeability, rendering it particularly relevant for investigations into transdermal transport mechanisms, peptide-membrane interactions, and the development of novel delivery vectors. The compound's utility extends to diverse fields such as pharmaceutical technology, dermatological science, and peptide engineering, where understanding and harnessing skin penetration is of central importance.
Transdermal delivery research: Transdermal Peptide is widely utilized in studies aiming to elucidate the mechanisms and efficiency of peptide-facilitated skin permeation. Researchers employ this compound to model and quantify the ability of peptides to traverse the stratum corneum and reach underlying tissues. Its application enables systematic evaluation of molecular features that influence transdermal flux, supporting the rational design of new delivery agents and enhancing the predictive accuracy of in vitro skin permeation assays.
Membrane interaction studies: The compound serves as a valuable probe for investigating peptide-lipid and peptide-protein interactions within the context of biological membranes. By examining how it associates with, disrupts, or translocates across lipid bilayers, scientists can gain insights into the fundamental biophysical processes governing membrane permeability. Such studies are instrumental in advancing the understanding of peptide structure-activity relationships and the factors that modulate translocation efficiency.
Peptide engineering and optimization: Transdermal Peptide is employed in peptide design and optimization workflows that seek to improve percutaneous transport properties. Through systematic modification and testing, researchers can use it as a reference or starting scaffold to develop analogues with tailored skin penetration capabilities. These efforts contribute to the advancement of peptide-based vectors and the refinement of molecular design strategies for enhanced delivery across biological barriers.
Analytical method development: The compound is frequently incorporated into analytical protocols aimed at detecting, quantifying, and characterizing peptides in complex biological matrices, such as skin extracts or receptor fluids. Its defined structure and behavior make it a suitable standard or control in chromatographic, spectrometric, or electrophoretic methods. Utilization in this context supports the validation of analytical techniques and ensures the reliability of experimental data in transdermal research.
Formulation science: Transdermal Peptide provides a model system for evaluating the compatibility and performance of excipients, penetration enhancers, and formulation technologies intended to promote peptide delivery through the skin. By incorporating it into prototype formulations, scientists can systematically assess the impact of various formulation parameters on stability, release profile, and skin permeation. These studies are critical for optimizing delivery vehicles and understanding the interplay between peptide properties and formulation components in the context of transdermal transport.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More