1. Home
  2. Products
  3. Therapeutic Peptides
  4. Peptide Inhibitors
  5. Trofinetide

Trofinetide

Trofinetide is a synthetic analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth factor 1 protein, and has demonstrated clinical benefit in phase 2 studies in Rett syndrome.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Trofinetide(CAS 853400-76-7)

CAT No: R1973

CAS No:853400-76-7

Synonyms/Alias:Trofinetide;853400-76-7;NNZ-2566;DAYBUE;Trofinetide [INN];trofinetida;L-Glutamic acid, glycyl-2-methyl-L-prolyl-;UNII-Z2ME8F52QL;ACP-2566;Z2ME8F52QL;Trofinetide [USAN];glycyl-L-2-methylprolyl-L-glutamic acid;Trofinetide(NNZ2566);Glycyl-2-methyl-L-prolyl-L-glutamic acid;(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid;Trofinetide (>90%);((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid;trofinetidum;Glycyl-2-methyl-L-prolyl-L-glutamic Acid; Glycyl-L-2-methylprolyl-L-glutamic Acid; NNZ 2566;NNZ 2566;Daybue (TN);Trofinetide (USAN/INN);Trofinetide [USAN:INN];TROFINETIDE [WHO-DD];CHEMBL197084;SCHEMBL1170014;GTPL12482;NNZ2566;CHEBI:229599;DTXSID101336041;GLXC-15737;DJB40076;EX-A7815;WHO 10076;AKOS030607026;analogue 4 [PMID: 15837309];AT37725;CS-8154;DB06045;DA-68364;HY-16757;MS-24628;glycyl-alpha-methyl-L-prolyl-L-glutamic acid;D12400;Q27294917;

Chemical Name:(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C13H21N3O6
M.W/Mr.
315.32
Sequence
One Letter Code:GXE
Three Letter Code:H-Gly-aMePro-Glu-OH
Appearance
Solid
Long-term Storage Conditions
Soluble to 100 mM in water and to 50 mM in DMSO with gentle warming
InChI
InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
InChI Key
BUSXWGRAOZQTEY-SDBXPKJASA-N
Canonical SMILES
CC1(CCCN1C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES
C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
BoilingPoint
655.4±55 ℃
Melting Point
144 ℃

Useful Tools

Peptide Calculator

Abbreviation List

Peptide Glossary

If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.

Featured Services
Peptide Analysis ServicesPeptide CDMOEpitope Mapping ServicescGMP Peptide ServiceCustom Conjugation ServicePeptide Modification ServicesPeptide Nucleic Acids SynthesisPeptide Synthesis Services
Hot Products
Elcatonin Acetate

Elcatonin Acetate is a calcitonin analog supporting bone metabolism research. Buy Elcatonin peptide online to study calcium regulation and osteoporosis.

Read More Read More
Fertirelin Acetate

Fertirelin Acetate is a synthetic peptide that promotes ovulation and fertility. Purchase Fertirelin research peptide for breeding and hormonal studies.

Read More Read More
Terlipressin Acetate

Terlipressin Acetate is a synthetic vasopressin analog peptide used for vascular and liver research. Buy Terlipressin peptide powder online from a trusted peptide supplier for professional studies.

Read More Read More
Angiotensin II Acetate

Angiotensin II Acetate is a potent research peptide regulating blood pressure and vascular tone. Purchase this synthetic peptide to support cardiovascular and renal studies.

Read More Read More
Carbetocin

Carbetocin is a synthetic oxytocin analog that promotes uterine contraction and postpartum recovery. Buy Carbetocin peptide powder from a professional supplier for reproductive research.

Read More Read More
Atosiban

Atosiban is a peptide oxytocin receptor antagonist that helps prevent preterm labor. Buy Atosiban peptide for reproductive and uterine contractility research.

Read More Read More
Somatostatin

Somatostatin peptide inhibits the secretion of growth hormone and insulin. Purchase high-purity Somatostatin for metabolic, neuroendocrine, and cancer research.

Read More Read More
Lanreotide Acetate

Lanreotide Acetate is a somatostatin analog peptide regulating hormone secretion. Purchase Lanreotide peptide online to study tumor suppression and endocrine disorders.

Read More Read More
Angiotensin II

Angiotensin II peptide regulates blood pressure and vascular constriction. Purchase this synthetic research peptide to support cardiovascular and renal function studies.

Read More Read More
DOTA-cyclo(RGDfK) acetate

DOTA-cyclo(RGDfK) Acetate is a radiolabeled peptide for tumor imaging and targeting research. Purchase this high-purity peptide for oncology and diagnostic studies.

Read More Read More
About us

Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.

From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.

Our Customers