Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF2α and mCRF2β, respectively.
CAT No: R1741
CAS No:171543-83-2
Synonyms/Alias:Urocortin (rat);171543-83-2;DA-68498;
Urocortin, rat is a peptide compound belonging to the corticotropin-releasing factor (CRF) family, characterized by its structural similarity to CRF and its role as a neuropeptide in the central nervous system. As a naturally occurring peptide in rats, urocortin modulates a range of physiological processes, including stress response, appetite regulation, and cardiovascular function. Its high sequence homology with other CRF-related peptides and its selective receptor affinities make it a valuable molecular tool for dissecting the complex signaling pathways involved in neuroendocrine regulation and stress adaptation. Urocortin's unique biochemical profile underpins its significance in fundamental research exploring the molecular mechanisms of stress, behavior, and homeostasis.
Neuroendocrine signaling research: Urocortin is extensively employed in studies investigating the mechanisms of hypothalamic-pituitary-adrenal (HPA) axis regulation. By acting as an agonist at CRF receptors, particularly CRF receptor type 2, it enables researchers to delineate the peptide's role in modulating adrenocorticotropic hormone (ACTH) release and downstream glucocorticoid production. Experimental applications include in vitro receptor binding assays, ex vivo tissue studies, and in vivo models to clarify how CRF-family peptides orchestrate neuroendocrine responses to environmental stressors.
Behavioral neuroscience: The peptide is a critical tool in behavioral paradigms designed to elucidate the neurochemical basis of anxiety, depression, and stress-related behaviors in rodents. Through intracerebral or systemic administration, urocortin facilitates the analysis of peptide-induced changes in locomotor activity, anxiety-like behavior, and feeding patterns. Its use in such studies provides insight into the functional interplay between neuropeptidergic signaling and behavioral outcomes, supporting the identification of potential molecular targets for modulating affective states in preclinical models.
Cardiovascular physiology: Urocortin's vasodilatory and cardioprotective properties have established its utility in cardiovascular research, particularly in the context of peptide-mediated regulation of blood pressure and cardiac function. Researchers employ the peptide in isolated tissue experiments and whole-animal models to investigate its effects on vascular tone, myocardial contractility, and the underlying signaling pathways involving cyclic AMP and nitric oxide. These studies contribute to a deeper understanding of neuropeptide contributions to cardiovascular homeostasis and stress adaptation.
Receptor pharmacology: The specificity of urocortin for CRF receptor subtypes makes it an essential ligand in pharmacological profiling and receptor characterization experiments. By serving as a reference agonist or competitor in binding studies, it enables precise mapping of receptor distribution, ligand-receptor interactions, and downstream signaling cascades. Such applications are fundamental for the development of selective receptor modulators and for advancing knowledge of peptide-GPCR (G protein-coupled receptor) signaling dynamics.
Peptide structure-function analysis: Urocortin is frequently used in structure-activity relationship (SAR) investigations to identify critical amino acid residues responsible for receptor binding and biological activity. By synthesizing analogs and variants of the peptide, researchers can systematically assess how specific sequence modifications influence receptor selectivity, potency, and signaling efficacy. These studies not only enhance the understanding of peptide-receptor interactions but also inform the rational design of novel peptide-based research tools and molecular probes.
2. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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