Vicatertide is a synthetic peptide designed to model integrin or matrix-binding epitopes with enhanced stability. Its sequence arranges hydrophobic and charged residues to form well-defined binding surfaces. Researchers examine its secondary structure, receptor affinity, and resistance to proteolysis. Applications include cell-adhesion studies, peptide-material conjugates, and ligand-optimization research.
CAT No: R2596
CAS No:1251838-01-3
Synonyms/Alias:Vicatertide;HY-P5542;CS-0887146;1251838-01-3;
Vicatertide is a synthetic peptide compound designed to mimic or modulate the activity of endogenous peptide hormones, making it a valuable tool in biochemical and physiological research. As a structurally defined peptide, it offers precise control over sequence and function, enabling detailed studies into peptide-receptor interactions, signal transduction pathways, and metabolic regulation. Its robust stability and well-characterized properties allow for consistent and reproducible results, supporting a wide range of investigative and experimental applications in academic, pharmaceutical, and industrial laboratories.
Peptide receptor binding studies: Researchers utilize Vicatertide to investigate the affinity and specificity of peptide-receptor interactions, particularly in systems where peptide signaling plays a central regulatory role. By serving as a ligand in receptor binding assays, this compound helps elucidate the molecular determinants of receptor activation and inhibition, providing insight into the structure-activity relationships that govern peptide-mediated signal transduction. Such studies are fundamental for mapping receptor pharmacology and for the rational design of novel modulators.
Cell signaling pathway analysis: In cell-based assays, Vicatertide is frequently employed to probe the downstream effects of peptide hormone signaling. Its defined sequence allows for the selective activation or inhibition of specific signaling cascades, enabling the dissection of pathways involved in cellular growth, differentiation, or metabolic control. By modulating intracellular responses, it facilitates the identification of key mediators and regulatory nodes within complex biological networks, supporting both basic and translational research objectives.
Peptide structure-function relationship exploration: The compound serves as a model system for analyzing how sequence modifications influence peptide function. Through systematic substitution or truncation experiments, researchers can use Vicatertide to delineate the critical residues responsible for bioactivity, stability, and receptor interaction. These studies are essential for advancing the understanding of peptide engineering principles and for guiding the development of next-generation peptide analogs with tailored properties.
Analytical method development: Laboratories leverage Vicatertide as a reference standard or spike-in control for the validation of peptide quantification techniques, such as liquid chromatography-mass spectrometry (LC-MS) or high-performance liquid chromatography (HPLC). Its defined composition and predictable chromatographic behavior make it an ideal candidate for calibrating instruments, optimizing separation protocols, and assessing analytical sensitivity and reproducibility. This ensures robust and accurate measurement of peptide analytes in complex biological matrices.
Peptide synthesis and formulation research: The compound is also utilized in the optimization of solid-phase peptide synthesis protocols and formulation strategies. By serving as a test substrate, Vicatertide enables the evaluation of coupling efficiencies, purification methods, and stability-enhancing excipients. Insights gained from these studies contribute to improved synthetic yields, enhanced peptide purity, and greater stability in storage and handling, which are critical for both research and industrial-scale peptide production.
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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