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xStAx-VHLL

xStAx-VHLL is a stapled α-helical peptide designed to stabilize hydrophobic and charged residues in a rigid conformation. The staple enforces helical geometry and enhances proteolytic resistance. Researchers examine its PPI-inhibitor potential and conformational behavior. Applications include helix-mimetic development, structural biophysics, and ligand optimization.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R2838

Synonyms/Alias:xStAx-VHLL;β-catenin degrader xStAx-VHLL; GLXC-25272

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C154H244N48O29
M.W/Mr.
3231.9
Sequence
One Letter Code:Ac-RRWPR{S5}ILD{S5}HVRRVWR-{Ahx}-ALAPYIP-NH2
Three Letter Code:Ac-Arg-Arg-Trp-Pro-Arg-{S5}-Ile-Leu-Asp-{S5}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2
InChI
InChI=1S/C154H244N48O29/c1-18-87(11)121-141(226)190-108(73-84(5)6)131(216)188-112(78-118(206)207)136(221)199-153(16,60-30-22-20-21-23-31-61-154(17,146(231)197-121)198-135(220)106(51-38-68-175-152(166)167)185-137(222)116-54-41-71-202(116)143(228)113(76-94-80-177-100-45-29-27-43-98(94)100)192-128(213)103(48-35-65-172-149(160)161)183-126(211)102(181-91(15)203)47-34-64-171-148(158)159)145(230)193-111(77-95-81-168-82-178-95)134(219)195-119(85(7)8)139(224)186-104(49-36-66-173-150(162)163)127(212)184-105(50-37-67-174-151(164)165)129(214)194-120(86(9)10)140(225)191-110(75-93-79-176-99-44-28-26-42-97(93)99)132(217)182-101(46-33-63-170-147(156)157)125(210)169-62-32-24-25-55-117(205)179-89(13)124(209)187-107(72-83(3)4)130(215)180-90(14)142(227)201-70-40-53-115(201)138(223)189-109(74-92-56-58-96(204)59-57-92)133(218)196-122(88(12)19-2)144(229)200-69-39-52-114(200)123(155)208/h20-21,26-29,42-45,56-59,79-90,101-116,119-122,176-177,204H,18-19,22-25,30-41,46-55,60-78H2,1-17H3,(H2,155,208)(H,168,178)(H,169,210)(H,179,205)(H,180,215)(H,181,203)(H,182,217)(H,183,211)(H,184,212)(H,185,222)(H,186,224)(H,187,209)(H,188,216)(H,189,223)(H,190,226)(H,191,225)(H,192,213)(H,193,230)(H,194,214)(H,195,219)(H,196,218)(H,197,231)(H,198,220)(H,199,221)(H,206,207)(H4,156,157,170)(H4,158,159,171)(H4,160,161,172)(H4,162,163,173)(H4,164,165,174)(H4,166,167,175)/b21-20-/t87-,88-,89-,90-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,119-,120-,121-,122-,153-,154-/m0/s1
InChI Key
NYZLXWJSWCBINW-OBGJTUHRSA-N

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