Z-D-Arg(NO2)-OH is a protected, stereochemically specified amino acid derivative in which D-arginine bears a nitro-substituted guanidino side chain (Arg(NO2)) and the alpha-amino group is protected as a benzyloxycarbonyl (Z, Cbz) carbamate. The molecule contains a free carboxylic acid (-CO2H) and a Z-protected amino group, while the side chain retains a guanidino functionality substituted with a nitro group that can influence hydrogen-bonding and electronic character. Z-D-Arg(NO2)-OH is used as a building block for peptide and peptidomimetic synthesis and for chemical biology or labeling workflows where a nitro-functionalized arginine analogue is incorporated or handled as a defined, protected intermediate.
3. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
4. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
5. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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