Z-L-Gla(OtBu)2-OH is a protected, amino-acid derivative of L-glutamic acid in which the alpha-amino group is masked as a Z (benzyloxycarbonyl, Cbz-like) carbamate and the side-chain carboxyl group is converted to two tert-butyl ester groups (OtBu) to give a di-tert-butyl protected glutamate. The molecule contains a free carboxylic acid at the alpha position (-CO2H) while the side-chain carboxyl functionality is esterified, and the stated L stereochemistry defines the configuration at the alpha carbon. Z-L-Gla(OtBu)2-OH is used as a protected building block for stepwise peptide synthesis and related derivatization workflows where orthogonal protection and controlled deprotection of the amino and carboxyl functionalities support chemoselective coupling and downstream peptide or amino-acid derivative preparation.
CAT No: CP25931
CAS No:60686-50-2
Synonyms/Alias:N-Hydroxysuccinimide;6066-82-6;1-hydroxypyrrolidine-2,5-dione;HOSu;1-Hydroxysuccinimide;1-Hydroxy-2,5-pyrrolidinedione;Hydroxysuccinimide;2,5-Pyrrolidinedione,1-hydroxy-;N-Hydroxysuccinimde;Succinimide,N-hydroxy-;N-hydroxysuccinimid;N-Hydroxylsuccinimide;N-hydroxy-succinimide;N-Hydroxy-2,5-pyrrolidinedione;UNII-MJE3791M4T;1-hydroxypyrrolidin-2,5-dion;CCRIS2604;NQTADLQHYWFPDB-UHFFFAOYSA-N;EINECS228-001-3;MFCD00005516;NSC74335;NHS;N-hyroxysuccinimide;2,1-hydroxy-;PubChem10972
Chemical Name:N-alpha-Benzyloxycarbonyl-gamma-carboxy-L-glutamic-acid-gamma-di-t-butyl ester
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