Z-L-Pro-ONp

Z-L-Pro-ONp is a protected amino acid derivative consisting of L-proline bearing an N-benzyloxycarbonyl (Z, Cbz) protecting group and an ONp ester at the carboxylate, forming a proline-based amino acid ONp ester. The molecule contains a carbamate-protected amino functionality and a carboxylate ester linkage to the p-nitrophenyl (ONp) leaving group, with stereochemistry consistent with the L-proline configuration indicated in the name. Z-L-Pro-ONp is used as an activated proline building block in peptide synthesis and related coupling workflows, where the ONp ester can participate in acyl transfer chemistry to assemble peptide bonds under appropriate conditions.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP25756

CAS No:3304-59-4

Synonyms/Alias:Z-Pro-ONp;3304-59-4;(S)-1-Benzyl2-(4-nitrophenyl)pyrrolidine-1,2-dicarboxylate;ST50409578;benzyloxycarbonyl-l-proline4-nitrophenylester;3304-54-9;Z-L-Pro-ONp;C4877_SIGMA;SCHEMBL4613447;CTK8G3869;GXUFIJVKXYWCAO-KRWDZBQOSA-N;MolPort-003-910-290;ZINC4578893;N-Cbz-L-Prolinep-nitrophenylester;N-CBZ-L-proline4-nitrophenylester;AKOS016003309;VZ31396;AK-81337;KB-251023;FT-0634770;ST24032088;BENZYLXOYCARBONYL-L-PROLINE4-NITROPHENYLESTER;1-[(Phenylmethoxy)carbonyl]-L-proline4-nitrophenylester;1-benzyl2-(4-nitrophenyl)(2S)-pyrrolidine-1,2-dicarboxylate;phenylmethyl(2S)-2-[(4-nitrophenyl)oxycarbonyl]pyrrolidinecarboxylate

Chemical Name:N-alpha-Benzyloxycarbonyl-L-proline p-nitrophenyl ester

Custom Peptide Synthesis

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C19H18N2O6

M.W/Mr.

370,35 g/mole

Size

5 g;25 g;

InChI

1S/C19H18N2O6/c22-18(27-16-10-8-15(9-11-16)21(24)25)17-7-4-12-20(17)19(23)26-13-14-5-2-1-3-6-14/h1-3,5-6,8-11,17H,4,7,12-13H2/t17-/m0/s1

InChI Key

GXUFIJVKXYWCAO-KRWDZBQOSA-N

Canonical SMILES

C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)OC3=CC=C(C=C3)[N+](=O)[O-]

1. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

3. Uncarboxylated osteocalcin decreases insulin-stimulated glucose uptake without affecting insulin signaling and regulators of mitochondrial biogenesis in myotubes

4. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs

5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate

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