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  5. Z-VRPR-FMK trifluoroacetate salt

Z-VRPR-FMK trifluoroacetate salt

A selective, irreversible and cell permeable MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1085

Synonyms/Alias:Z-VRPR-FMK;CHEMBL4459733;Z-VRPR-FMK (trifluoroacetate salt);SCHEMBL18619548;BDBM50510283;1381885-28-4;PD194003;HY-120231;CS-0077259;benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-[[(3S)-6-(diaminomethylideneamino)-1-fluoro-2-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C31H49FN10O6.CF3CO2H
M.W/Mr.
790.81
Sequence
One Letter Code:VRPR
Three Letter Code:Cbz-Val-Arg-Pro-Arg-CH2F
Labeling Target
MALT1
Appearance
Solid powder
Purity
>90%
Activity
Inhibitor
InChI
InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1
InChI Key
WIPHXOQUHDJLCU-WTJMUODPSA-N
Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O

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