γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).
CAT No: R1799
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a synthetic peptide derivative belonging to the melanocortin family, recognized for its role in modulating various physiological processes through interaction with melanocortin receptors. Structurally, it features an amidated C-terminus, which may enhance its stability and receptor affinity compared to its non-amidated counterparts. The peptide is of significant interest in biochemical research due to its involvement in signaling pathways that influence pigmentation, energy homeostasis, and inflammatory responses. Its utility as a research tool extends to investigations of receptor pharmacology, peptide-receptor binding dynamics, and downstream cellular effects, making it a valuable compound for studies in molecular and cellular biology.
Receptor binding studies: As a selective agonist for melanocortin receptors, particularly MC1R and MC3R, γ-1-MSH amide is widely employed in receptor binding assays. Researchers utilize the peptide to characterize receptor subtype specificity, binding kinetics, and signal transduction mechanisms. Its defined structure and amidated form enable precise assessment of ligand-receptor interactions, facilitating the development of pharmacological models and the identification of potential allosteric sites within the melanocortin receptor family.
Cell signaling research: The compound serves as a potent tool for dissecting intracellular signaling cascades initiated by melanocortin receptor activation. By applying γ-1-MSH amide to cultured cells or tissue preparations, investigators can monitor changes in second messenger levels, such as cyclic AMP, and elucidate downstream effects on gene expression. These studies provide crucial insights into the modulation of cellular pathways involved in pigmentation, metabolic regulation, and immune responses, enabling a deeper understanding of the functional consequences of peptide-receptor engagement.
Peptide structure-activity relationship (SAR) analysis: The unique sequence and terminal modification of γ-1-MSH amide make it an ideal candidate for structure-activity relationship studies. Researchers employ this peptide to probe the impact of specific amino acid substitutions and terminal modifications on receptor affinity and biological activity. Such investigations inform the rational design of novel peptide analogs with tailored pharmacological profiles, supporting the advancement of peptide-based research tools and therapeutics in preclinical settings.
Peptide synthesis and analytical method development: As a reference standard, γ-1-MSH amide is utilized in the optimization of solid-phase peptide synthesis protocols and the validation of analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its well-characterized physicochemical properties assist in benchmarking synthesis efficiency and purity assessment, contributing to the refinement of peptide production and quality control workflows in research laboratories.
Functional studies in pigmentation biology: The peptide is instrumental in experimental models exploring melanogenesis and pigment cell biology. By modulating melanocortin receptor activity in melanocytes or pigment-producing systems, γ-1-MSH amide enables the investigation of regulatory mechanisms underlying melanin synthesis, pigment dispersion, and cellular responses to environmental stimuli. These studies are foundational for advancing knowledge in skin biology, photobiology, and the broader field of pigment cell research.
2. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
3. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
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