A11 is a short, engineered peptide motif containing hydrophobic and charged residues arranged to explore binding-site complementarity. Its compact structure enables flexible conformational sampling in solution. Researchers use it for protein-surface screening and early-stage ligand discovery. Applications include probe optimization, SAR evaluations, and motif-function analysis.
CAT No: R2783
CAS No:2412926-30-6
Synonyms/Alias:CPP-EYVQTVKSSKG；YGRKKRRQRRREYVQTVKSSKG;L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-L-lysyl-L-seryl-L-seryl-L-lysyl-glycine
A11 is a synthetic peptide compound characterized by a defined amino acid sequence, designed for advanced biochemical and molecular biology research. As a member of the peptide class, A11 exhibits properties that make it particularly valuable for studies involving protein-protein interactions, receptor binding, and cellular signaling pathways. Its sequence specificity and structural features allow for targeted investigations into biological processes at the molecular level, supporting a range of experimental applications. Researchers leverage the unique characteristics of A11 to dissect complex biological mechanisms, making it a critical tool in the expanding field of peptide-based research.
Protein-Protein Interaction Studies: In the context of elucidating protein-protein interactions, A11 serves as a model peptide for mapping binding domains and characterizing interaction specificity. Its defined sequence enables researchers to probe the molecular determinants of binding events, facilitating the identification of critical contact residues and interaction motifs. By employing this peptide in affinity assays, pull-down experiments, or surface plasmon resonance studies, scientists can gain mechanistic insights into how proteins recognize and interact with peptide partners, advancing the understanding of cellular signaling networks.
Receptor Binding Assays: A11 is frequently utilized in receptor-ligand binding studies to assess affinity, selectivity, and activation properties of peptide-responsive receptors. Its application in radioligand binding assays, fluorescence polarization, or biolayer interferometry allows for the quantitative evaluation of receptor engagement. These investigations are essential for characterizing the pharmacological profiles of peptide-receptive targets, supporting both basic research and early-stage drug discovery efforts focused on peptide mimetics and antagonists.
Cell Signaling Pathway Analysis: The peptide is instrumental in dissecting cell signaling mechanisms, particularly those involving peptide-mediated signal transduction. By introducing A11 into cultured cells or in vitro systems, researchers can monitor downstream biochemical events such as phosphorylation, second messenger generation, or transcriptional activation. This approach enables the functional analysis of signaling cascades, helping to clarify how specific peptide sequences modulate cellular responses and regulatory pathways.
Peptide Structure-Activity Relationship (SAR) Studies: A11 supports structure-activity relationship investigations, where systematic modifications to its sequence or chemical structure are correlated with changes in biological activity. Through alanine scanning, truncation, or incorporation of non-natural amino acids, scientists can delineate the structural features critical for function. The data generated from these studies inform the rational design of optimized peptides with enhanced stability, potency, or selectivity, underpinning advancements in peptide engineering and molecular design.
Analytical Method Development: The well-defined nature of A11 makes it a suitable reference or calibration standard in the development and validation of peptide analysis techniques. It is employed in high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis protocols to optimize separation conditions, assess instrument sensitivity, and ensure reproducibility. The use of such synthetic peptides as analytical benchmarks enhances the reliability and accuracy of peptide quantification and characterization workflows in research and quality control laboratories.
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