Ac-beta-Ala-NH2 contains an acylated β-alanine backbone in which the amino acid nitrogen is converted to an acetamide (Ac-) while the molecule retains a terminal primary amide functionality (-NH2) at the other end, classifying it as an amino acid derivative rather than an unprotected free amino acid. The structure features the β-amino acid framework with an amide-linked carboxyl equivalent and a free primary amine, giving it a bifunctional profile suitable for further conjugation or coupling chemistry while limiting reactivity at the acylated site. Ac-beta-Ala-NH2 is used in peptide-related and chemical biology workflows as a precursor or building block for assembling more complex amino acid derivatives, preparing amide-linked structures, and supporting analytical or synthetic studies that require a β-alanine motif with controlled functional group availability.
CAT No: CP25410
CAS No:15962-47-7
Chemical Name:N-Acetyl-beta-alanine amide
Ac-beta-Ala-NH2 is an N-acetylated β-alanine amide (Ac-β-Ala-NH2), providing a protected/activated carboxyl terminus as an acetamide while retaining a primary amide at the β-alanine end. This structure makes it a convenient, non-zwitterionic building block for peptide-related synthesis and for preparing amide-linked standards where a defined β-alanine motif is required. Because the molecule contains only amide functionalities and lacks a free carboxylic acid, it is commonly selected when downstream workflows require controlled reactivity and consistent analytical behavior.
1. Peptide Segment Building
Ac-beta-Ala-NH2 is used as a defined β-alanine-containing amide building block in peptide segment assembly where an N-acetylated, carboxamide-like terminus is desired. Researchers preparing short peptides, peptidomimetic fragments, or β-alanine-based linkers often choose this reagent to introduce a β-alanine unit without requiring additional carboxyl activation steps for that segment. In custom peptide synthesis workflows, the amide-only functionality helps maintain compatibility with coupling strategies that target other peptide positions while keeping the β-alanine terminus in a stable, non-acid form.
2. Amide-Linked Intermediate Synthesis
Ac-beta-Ala-NH2 serves as a practical intermediate for constructing amide-linked compounds in medicinal chemistry and specialty chemical development. The N-acetylated β-alanine amide format provides a stable scaffold for further derivatization at positions outside the β-alanine unit, enabling controlled incorporation of a β-alanine motif into larger heterocycles, side-chain analogs, or linker systems. Pharmaceutical intermediate developers often rely on such amide-terminated amino acid derivatives to standardize building blocks used across parallel synthesis campaigns and to reduce variability associated with carboxylic acid handling.
3. Analytical Reference and LC-MS Standards
Ac-beta-Ala-NH2 is frequently employed as an analytical reference material for method development and verification in LC-MS workflows targeting β-alanine-derived amide species. Its well-defined structure and lack of a free carboxyl group make it useful for calibrations, retention-time checks, and mass-based identification of β-alanine amide fragments generated during sample processing or analytical derivatization. Analytical chemists and bioanalytical teams use Ac-beta-Ala-NH2 when they need a structurally specific standard that reflects an amide-terminated β-alanine motif rather than the corresponding free amino acid.
3. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
5. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More