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ADAM-17 Substrate

ADAM-17 Substrate is a peptide sequence engineered to reflect preferred cleavage motifs of ADAM-17 metalloprotease. Hydrophobic and polar residues flank the scissile bond to tune specificity. Researchers use it in kinetic assays to quantify catalytic efficiency and inhibitor potency. Applications include sheddase-mechanism studies, substrate profiling, and drug-discovery screening.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: Z10-101-231

Synonyms/Alias:ADAM-17 Substrate; HY-P10174; CS-0912082

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C59H92N22O21
M.W/Mr.
1445.5
Sequence
One Letter Code:XLAQAVRSSSRX
Three Letter Code:H-2Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dap(Dnp)(Dnp)-OH
InChI
InChI=1S/C59H92N22O21/c1-27(2)21-38(74-48(88)32-11-7-8-12-33(32)60)52(92)70-29(5)46(86)71-37(17-18-44(61)85)49(89)69-30(6)47(87)79-45(28(3)4)56(96)73-36(14-10-20-67-59(64)65)51(91)76-41(25-83)54(94)78-42(26-84)55(95)77-40(24-82)53(93)72-35(13-9-19-66-58(62)63)50(90)75-39(57(97)98)23-68-34-16-15-31(80(99)100)22-43(34)81(101)102/h7-8,11-12,15-16,22,27-30,35-42,45,68,82-84H,9-10,13-14,17-21,23-26,60H2,1-6H3,(H2,61,85)(H,69,89)(H,70,92)(H,71,86)(H,72,93)(H,73,96)(H,74,88)(H,75,90)(H,76,91)(H,77,95)(H,78,94)(H,79,87)(H,97,98)(H4,62,63,66)(H4,64,65,67)/t29-,30-,35-,36-,37-,38-,39-,40-,41-,42-,45-/m0/s1
InChI Key
RRTVIQGBLVYLQM-GHWPXLJNSA-N

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